Game Details
Kickoff: 8:20 PM ET (5:20 PM PT)
Venue: Highmark Stadium, One Bills Drive, Orchard Park, NY 14127
Surface: Natural Grass
Broadcast: NBC: Mike Tirico, Cris Collinsworth, Melissa Stark (field reporter) Westwood One: Ryan Radtke, Mike Golic
Weather: ~47°F at kickoff, partly cloudy, ~25% chance of light rain, winds 6–9 mph — cool, potentially slick conditions
Injury Report
Baltimore Ravens
Mark Andrews (TE) – Healthy; returns from late‑2024 injury
Jaire Alexander (CB) – Healthy; offseason acquisition from Green Bay
No major offensive injuries reported
Buffalo Bills
Joey Bosa (EDGE) – Questionable (soft‑tissue)
James Cook (RB) – Active after preseason holdout; conditioning worth monitoring
No other significant absences reported
Team Records & Recent Form
2024 Recap:
Ravens: 13‑4, AFC North champions; lost 27‑25 to Buffalo in Divisional Round
Bills: 12‑5, AFC East champions; lost AFC Championship to Kansas City
Recent Head‑to‑Head:
Ravens lead regular‑season series 7‑4
Bills 2‑0 vs Ravens in postseason (2021, 2024)
Quarterback Note: Lamar Jackson is 3‑1 vs. Josh Allen in regular season; Allen 2‑0 vs. Jackson in playoffs
Betting Trends
Ravens 5‑1 ATS in last 6 season openers
Bills 7‑2 SU in last 9 home openers
Under has hit in 4 of last 6 meetings
Home team is 4‑1 SU in last 5 matchups
RAVENS NOTES:
• RAVENS have won 7 of past 9 Week 1 games. Aim for 4th win in row on SNF. • QB LAMAR JACKSON became 1st player in NFL history with 4,000+ pass yards (4,172), 40+ TD passes (41) & fewer than 5 INTs (4) in 2024. Had 125+ rating in 8 games, 2nd-most in single-season all-time. Finished season with 2+ TDs in 8 straight games, incl. playoffs, longest streak of career. Had 123.2 rating in 2 starts vs. Buf. last season, incl. playoffs. Has 13 TDs vs. 2 INTs with 117.4 rating in 6 career starts in Week 1. Is 7-1 in 8 career starts on SNF. • RB DERRICK HENRY ranked 2nd in NFL in 2024 with 2,114 scrimmage yards (1,921 rush, 193 rec.) & tied-2nd with 18 TDs (16 rush, 2 rec.), becoming 1st player in NFL history with 1,500+ rush yards & 15+ rush TDs in 3 career seasons. Has 505 rush yards (126.3 per game) & 4 TDs (3 rush, 1 rec.) in 4 career games on SNF. Has 10 TDs (9 rush, 1 rec.) in 7 career games vs. Buf. • WR ZAY FLOWERS led team with career-high 1,059 rec. yards last season. Has 15 catches (7.5 per game) in 2 career Week 1 games. • WR RASHOD BATEMAN set career highs in rec. yards (756) & rec. TDs (9) in 2024. Had TD catch in 5 of final 6 games, incl. playoffs. • WR DEANDRE HOPKINS can make Bal. debut. Leads active players with 12,965 rec. yards, ranks 2nd with 984 catches & 3rd with 83 rec. TDs. • TE MARK ANDREWS led TEs with career-high 11 rec. TDs in 2024. Can join HOFer Antonio Gates as only TEs ever with rec. TD in 7 straight reg. season games. • WR ISAIAH LIKELY set career highs in catches (42), rec. yards (477) & rec. TDs (6) in 2024. Had 73 rec. yards & TD catch in 2024 AFC-D vs. Buf. • LB ROQUAN SMITH ranked tied-4th in NFL with 154 tackles in 2024, becoming 1st player since 2000 with 150+ tackles in 4 straight seasons. • LB KYLE VAN NOY ranked 4th in NFL with career-high 12.5 sacks last season. Finished season with 0.5+ sacks in 6 of final 7 games, incl. playoffs. • LB ODAFE OWEH had career-high 10 sacks in 2024. • CB MARLON HUMPHREY had career-high 6 INTs with 15 PD in 2024. • CB JAIRE ALEXANDER can make Bal. debut after totaling 70 PD & 12 INTs over past 7 seasons with GB. Has INT in each of 2 career games vs. Buf. • S KYLE HAMILTON had career-best 107 tackles last season.
BILLS NOTES:
• BILLS finished 10-0 at home last season, incl. playoffs. • QB JOSH ALLEN won AP MVP last season after totaling 40 TDs (28 pass, 12 rush) vs. 6 INTs with 101.4 rating. Totaled 26 TDs (19 pass, 7 rush) vs. 3 INTs with 108.7 rating in 10 home games last season, incl. playoffs. Had 11 TDs (9 pass, 2 rush) vs. 0 INTs with 118.2 rating in 5 primetime starts last season. Had 2 rush TDs in 2024 AFC-D vs. Bal. • RB JAMES COOK tied for NFL lead with 16 rush TDs in 2024, tied for most in a season in franchise history. Had 82 scrimmage yards (67 rush, 15 rec.) in 2024 AFC-D vs. Bal. Had 5 TDs (4 rush, 1 rec.) in 4 primetime games last season. • RB RAY DAVIS was 1 of 3 rookie RBs with 600+ scrimmage yards (631) & 6+ TDs (6) last season. • WR KHALIL SHAKIR led team with career highs in catches (76) & rec. yards (821) in 2024. Had 6 catches for 67 yards in 2024 AFC-D vs. Bal. • WR KEON COLEMAN ranked 4th among AFC rookie WRs with 556 rec. yards in 2024. • WR JOSHUA PALMER can make Buf. debut after totaling 182 catches, 2,287 rec. yards & 10 rec. TDs over past 4 seasons with LAC (2021-24). • TE DALTON KINCAID has 117 catches since entering NFL in 2023. • DE GREG ROUSSEAU led team with career-high 16 TFL & 8 sacks last season. Had sack in 2024 AFC-D vs. Bal. • DE JOEY BOSA can make Buf. debut after totaling 72 sacks over past 9 seasons with Chargers (2016-24). Has 5 TFL & 2.5 sacks in 4 career games vs. Bal. Has sack in 4 of his past 5 on SNF. Has 7 sacks in 7 career Week 1 games. • DT ED OLIVER led all DTs with career-high 3 FFs in 2024. • LB DORIAN WILLIAMS led team with career-best 113 tackles in 2024. • CB CHRISTIAN BENFORD had team-high 10 PD last season. • CB TRE’DAVIOUS WHITE returns to Buf. after spending 2024 season with LAR & Bal., totaling 5 PD. Ranks 3rd among all Buf. players since 2000 with 68 PD.
Game Odds
Baltimore Ravens – 1
Buffalo Bills 46.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 6, 2025
