Game Details
Kickoff: 4:25 PM ET (1:25 PM PT)
Venue: Lumen Field, 800 Occidental Ave S, Seattle, WA 98134
Surface: FieldTurf
Broadcast: FOX: Joe Davis, Greg Olsen, Pam Oliver (field reporter)
Weather: Mostly sunny, ~72°F at kickoff, light NW winds 5–8 mph; minimal weather impact, but crowd noise expected to be a factor in communication
Injury Report
San Francisco 49ers
Brandon Aiyuk (WR) – Out (ACL recovery, expected return mid‑season)
Jauan Jennings (WR) – Out (calf)
Jacob Cowing (WR) – Out (hamstring)
Christian McCaffrey (RB) – Healthy; returns from Achilles/PCL injuries
Trent Williams (OT) – Healthy; back from 2024 injury layoff
Seattle Seahawks
Geno Smith (QB) – Traded in offseason; Sam Darnold now starter
DK Metcalf (WR) – Traded; replaced by Cooper Kupp in free agency
No major injury absences reported for Week 1
Team Records & Recent Form
2024 Recap:
49ers: 6‑11, last in NFC West; plagued by injuries, especially on offense
Seahawks: 10‑7, 2nd in NFC West; playoff berth, strong home record
Offseason Changes:
49ers: Lost Deebo Samuel, Charvarius Ward; added RB Brian Robinson Jr., DC Robert Saleh returns
Seahawks: Revamped passing game with QB Sam Darnold and WR Cooper Kupp; new OC Klint Kubiak
Series History: Seahawks lead all‑time 31‑20; SF won division in 2022 & 2023, SEA last won in 2020
Betting Trends
49ers 3‑1 ATS in last 4 vs Seahawks
Seahawks 7‑3 ATS in last 10 home games
Under has hit in 4 of last 6 meetings
Home underdog in this rivalry is 5‑2 ATS since 2018
49ERS NOTES:
• QB BROCK PURDY passed for 3,864 yards & had 25 TDs (20 pass, 5 rush) & 96.1 rating in 2024. Had 300+ pass yards & 2+ TD passes in 3 of final 4 games last season. Has 10 TDs (9 pass, 1 rush) vs. 108.4 rating in 5 starts vs. Sea. • RB CHRISTIAN MCCAFFREY has 948 scrimmage yards (158 per game) & 7 TDs (6 rush, 1 rec.) in 6 career games vs. Sea. incl. 100+ scrimmage yards in every game. Has 3,581 scrimmage yards (115.5 per game) & 31 TDs (20 rush, 11 rec.) in 31 reg. season games with SF since 2022. • RB BRIAN ROBINSON makes SF debut. had 958 scrimmage yards (careerhigh 799 rush, 159 rec.) & career-high 8 rush TDs in 2024. Had career-high 157 scrimmage yards (119 rec., 38 rush) & TD catch in his only career gamesvs. Sea. 11/12/23) • TE GEORGE KITTLE ranked tied-2nd among TEs in rec. TDs (8), 3rd in rec yards (1,106) & 5th in receptions (78) last season. Is 1 of 5 TEs all-time with 1000+ rec. yards in 4 career seasons. Has 7 rec. TDs in his past 5 vs. Sea. • WR JAUAN JENNINGS set career highs with 77 receptions for 975 yards & 5 TDs in 2024. Had 10 catches for 91 yards & TD in last meeting. • LB FRED WARNER is 1 of 2 (Bobby Wagner) with 115+ tackles in each of past 7 seasons. Had 11 tackles in last road meeting. • DL NICK BOSA has 45+ tackles, 9+ sacks & 15+ TFL in 5 of his 6 career seasons. Has 10 sacks in his past 8 vs. Sea. • DL MYKEL WILLIAMS was selected No. 11 in 2025 NFL Draft. • DL ALFRED COLLINS was selected in 2nd round (No. 43) overall in 2025 NFL Draft. • CB RENARDO GREEN ranked tied-2nd among rookies with 13 PD in 2024. • CB DEOMMODORE LENOIR had career-high 85 tackles last season. • S JI’AYIR BROWN had 77 tackles, 6 PD & 3 TFL last season. • S JASON PINNOCK makes SF debut. Had 85 tackles in each of past 2 seasons with NYG.
SEAHAWKS NOTES:
• QB SAM DARNOLD makes Sea. debut. Set career highs in pass yards (4,319), TD passes (35) & rating (102.5) in 2024 with Min. Passed for 268 yards & 2 TDs for 109.1 rating in his last start vs. SF (9/15/24 w/ Min.). Spent 2023 season with SF. • RB KENNETH WALKER III had career-high 46 catches with 872 scrimmage yards (573 rush, career-high 299 rec.) & 8 TDs (7 rush, 1 rec.) in 2024. Is 1 of 5 RBs with 8+ scrimmage TDs in each of past 3 seasons. Had rush TD in both games vs. SF last season. • RB ZACH CHARBONNET had 42 receptions, 909 scrimmage yards (569 rush, 340 rec) & 9 TDs (8 rush, 1 rec.) in 2024, all career highs. • WR JAXON SMITH-NJIGBA set career bests with 100 receptions for 1,130 yards & 6 TDs in 2024. Had 10 catches for 110 yards in last meeting. • WR COOPER KUPP makes Sea. debut. Had 634 receptions, 7,915 scrimmage yards & 58 TDs (57 rec., 1 rush) in 104 games (2017-24) with LAR. • DE LEONARD WILLIAMS had career-high 16 TFL & 11 sacks in 2024. Had 2+ sacks in 4 of his final 7 games last season, incl. Weeks 17-18. • DE DEMARCUS LAWRENCE makes Sea debut. Had 97 TFL, 61.5 sacks, 21 FF & 20 PD in 141 games (2014-24) with Dal. • LB ERNEST JONES had 138 tackles (w/ Ten. & Sea.) in 2024, his 3rd-straight 100+ tackle season. Had 13 tackles in last meeting. • LB TYRICE KNIGHT had 6+ tackles in 7 of his final 8 games in 2024, incl. 10 tackles in last meeting. • CB DEVON WITHERSPOON had career-high 98 tackles & 9 PD & 6 TFL last season. Had 3 PD in last meeting. • CB RIQ WOOLEN is only player with 40+ PD (41) & 10+ INTs (11) since 2022. • S JULIAN LOVE had 106 tackles, career-high 12 PD & 3 INTs last season & is 1 of 2 DBs (Kevin Byard) with 100+ tackles in each of past 3 seasons.
Game Odds
San Francisco 49ers – 2.5
Seattle Seahawks 43.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 6, 2025
