MLB Game Preview: Washington Nationals (56-83) vs. Chicago Cubs (80-60)

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Venue & First Pitch

  • Location: Wrigley Field, Chicago, Illinois
  • Date: Friday, September 5, 2025
  • Time: 2:20 PM ET
  • Broadcast: Apple TV+
  • Capacity: 41,649

Weather Forecast (Chicago, IL – First Pitch)

  • Conditions: Partly cloudy, warm
  • Temperature: ~78°F
  • Wind: W at 7–9 mph (slight boost to balls hit toward left field)
  • Precipitation: <10%
  • Impact: Favorable hitting conditions with mild wind

Injury Report

Nationals

  • No new major injuries; several rookies in lineup as part of September call-ups

Cubs

  • No significant changes to active roster; bullpen fully available

Recent Form

Washington Nationals (Last 5): W‑W‑W‑L‑L

  • Swept Miami in last series, outscoring them 17–7
  • Pitching allowed just 1 HR in that set

Chicago Cubs (Last 5): L‑W‑W‑L‑W

  • Took 2 of 3 from Atlanta before a 5‑1 loss in finale
  • Cade Horton tossed 5 no-hit innings in last start

Projected Starting Pitchers

  • WSH: RHP Jake Irvin (8‑10, 5.42 ERA, 1.41 WHIP)
    • Road: 6‑6, 5.76 ERA in 15 starts
    • Career vs. Cubs: 0‑3, 8.00 ERA in 4 starts
  • CHC: RHP Javier Assad (1‑1, 4.05 ERA, 1.35 WHIP)
  • Home: 0‑0, 2.25 ERA in 1 start
  • Career vs. Nationals: 1‑0, 3.38 ERA in 3 games (2 starts)

Key Player Matchups

  • CJ Abrams (WSH) vs. Javier Assad (CHC)
    • Abrams: 20 HR, 70 RBI; speed threat on basepaths
    • Assad: Relies on soft contact; must keep Abrams off base
  • Pete Crow-Armstrong (CHC) vs. Jake Irvin (WSH)
    • PCA: 28 HR, 80+ RBI; power-speed combo
    • Irvin: Vulnerable to HRs (1.4 HR/9)
  • Seiya Suzuki (CHC) vs. Nationals Bullpen
  • Suzuki: Team-high 89 RBI; thrives vs. middle relief

Series History

  • All-Time: Nationals lead 335‑319‑1
  • 2025 Season Series: Cubs lead 2‑1
  • Recent: Cubs have won 5 of last 7 meetings

Betting Trends

  • Cubs: 10‑1 as -235 or greater favorite this season; OVER in 63 of 136 games
  • Nationals: 3‑9 as +194 or longer underdog; UNDER in 6 of last 8 road games
  • Cubs 8‑1 in last 9 home games vs. WSH

Game Odds

Washington Nationals                   9.5

Chicago Cubs                                     – 235

Odds Courtesy of Sports Odds Direct as of Thursday, September 4, 2025