Venue, Date & Time
Date: Friday, September 5, 2025
Kickoff: 8:00 p.m. ET / 7:00 p.m. CT / 5:00 p.m. PT / 9:00 p.m. BRT (local)
Venue: Arena Corinthians, Av. Miguel Ignácio Curi, 111 – São Paulo, Brazil
Capacity: ~49,205
Broadcast: YouTube: Rich Eisen, Kurt Warner, Stacey Dales (field reporter) Westwood One: Ryan Radtke, Dante Hall SiriusXM: Kansas City | Los Angeles
Weather Forecast (São Paulo, Brazil – Kickoff)
Conditions: Clear skies
Temperature: ~72°F (22°C)
Wind: 4–6 mph, light and variable
Precipitation: 0% chance — no weather‑driven impact expected
Impact: Ideal passing and kicking conditions
Injury Report
Kansas City Chiefs
WR Rashee Rice – Suspended (out)
WR Jalen Royals – Knee (DNP earlier in week, questionable)
WR Hollywood Brown – Ankle (full participant)
DL Omarr Norman‑Lott – Ankle (limited)
CB Kristian Fulton – Knee (full)
LB Drue Tranquill – Back (full)
T Jawaan Taylor – Knee (full)
TE Jared Wiley – Knee (full)
Los Angeles Chargers
RB Najee Harris – Eye (full participant)
S Elijah Molden – Knee (limited)
LT Rashawn Slater – Out for season (knee)
Key Player Matchups
Patrick Mahomes (KC) vs. Chargers Secondary
Mahomes is 9‑3 vs. LAC with 3,270 yards, 27 TD, 7 INT in 12 meetings.
Without Rice, rookie Xavier Worthy and TE Travis Kelce will be primary targets.
Justin Herbert (LAC) vs. Chiefs Pass Rush
Herbert has elite arm talent and now has Ladd McConkey (1,100+ yds as a rookie) and Keenan Allen back.
Chiefs’ Chris Jones anchors a front that must pressure Herbert without blitzing heavily.
Najee Harris (LAC) vs. Chiefs Run Defense
KC allowed 4.5 YPC late in 2024; Harris’ power running could control tempo.
Travis Kelce (KC) vs. Chargers Linebackers/Safeties
Kelce’s savvy route running remains a mismatch, especially in red zone.
Recent Form (2024 end):
KC: Lost Super Bowl LVIX to PHI (40‑22) after playoff wins over BUF and BAL.
LAC: Lost Wild Card to HOU (32‑12) after strong finish to regular season.
Series History
All‑Time: Chiefs lead 71‑58‑1 (including postseason)
Recent Trend: KC has won 7 straight vs. LAC.
Last Meeting: Week 14, 2024 – Chiefs 20, Chargers 17 (Arrowhead)
Betting Trends
Chiefs
7‑0 SU last 7 vs. Chargers
5‑2 ATS in last 7 vs. Chargers
Mahomes is 7‑0 in Week 1 starts
Chargers
4‑1 ATS in last 5 as underdog of 3+ points
Over is 6‑3 in last 9 head‑to‑head meetings
CHIEFS NOTES:
• CHIEFS have won 9 of past 10 Week 1 games. Are 3-0 in reg. season international games & can join Vikings as only teams to win 1st 4. • HC ANDY REID has 17 wins in season-opening games, most among active HCs. • QB PATRICK MAHOMES totaled 3,928 pass yards & 26 TD passes in 2024 & joined HOFer Peyton Manning (8 seasons) as only players ever with 3,500+ pass yards & 25+ TD passes in 7 of 1st 8 seasons. Has most TD passes (245) & 3rd-most pass yards (32,352) ever by QB in 1st 8 seasons. Is 6-0 with 14 TDs vs. 3 INTs & 107.6 rating in past 6 starts vs. LAC. Is 35-5 with 100.3 rating in 40 career starts vs. division. Is 6-1 with 22 TDs (21 pass, 1 rush) vs. 2 INTs & 122.8 rating in 7 career Week 1 starts. • RB ISIAH PACHECO has 2,528 (66.5 per game) scrimmage yards in 38 career game since entering NFL in 2022. Aims for his 4th in row vs. LAC with 60+ scrimmage yards. Has rush TD in 2 of 3 career Week 1 games. • RB KAREEM HUNT led team with 728 rush yards & 7 rush TDs in 2024. • TE TRAVIS KELCE ranked 3rd among TEs with 97 catches in 2024, becoming 1st player ever with 90+ catches in 7 straight seasons. Ranks 3rd all-time among TEs in catches (1,004) & rec. yards (12,151) & 5th in rec. TDs (77). Aims for his 12th in row vs. LAC with 5+ catches. Has rec. TD in 2 of 3 career international games. • WR XAVIER WORTHY ranked 6th among rookies last season with 6 rec. TDs. • DT CHRIS JONES is 1 of 4 in NFL with 5+ sacks in each of past 8 seasons. Has 10 TFL & 7 sacks in his past 6 vs. LAC. Has FF in each of his past 2 Week 1 games. • DE GEORGE KARLAFTIS led team with 8 sacks in 2024. • LB NICK BOLTON led team with 106 tackles in last season, 3rd-career 100-tackle season since entering NFL in 2021. • CB TRENT MCDUFFIE led team with career-high 13 PD in 2024. Aims for 3rd in row vs. LAC with PD. • CB KRISTIAN FULTON can make KC debut. Totaled 7 PD in 2024 with LAC.
CHARGERS NOTES:
• CHARGERS have won 5 of past 6 Week 1 games. Are 1-2 in reg. season international games. • HC JIM HARBAUGH is 5-0 in season-opening games. • QB JUSTIN HERBERT was only QB in NFL last season with 20+ TD passes (23) & 3-or-fewer INTs (3). Has 21,093 career pass yards & 1,945 completions, both most-ever by QB in 1st 5 seasons. Had 8 TDs vs. INT with 103.1 rating in 6 starts vs. division in 2024. Is 3-1 with 7 TDs (6 pass, 1 rush) vs. INT with 100.6 rating in 4 career Week 1 starts, with 0 INTs in each of past 3. • RB NAJEE HARRIS can make LAC debut. Totaled 5,461 scrimmage yards (4,312 rush, 1,149 rec.) & 34 TDs (28 rush, 6 rec.) over past 4 seasons with Pit. (2021- 24) & is 4th player since 1990 with 1,000+ rush yards & 7+ rush TDs in each of 1st 4 seasons. Has 191 scrimmage yards (95.5 per game) in 2 career games vs. KC. • RB OMARION HAMPTON was selected No. 22 overall in 2025 NFL Draft, Chargers’ 1st RB selected in 1st round since 2015 (Melvin Gordon). • WR LADD MCCONKEY ranked 4th among rookies last season in catches (82) & rec. yards (1,149) & tied-4th in rec. TDs (7). Finished season with 50+ rec. yards in 10 straight games. Had TD catch in only career game vs. KC (9/29/24). • WR KEENAN ALLEN returns to LAC after totaling 70 catches for 744 yards & 7 TDs in 2024 with Chi., 11th-career season with 700+ rec. yards. • LB KHALIL MACK is only player in NFL with 6+ sacks in each of past 10 seasons. Aims for his 4th in row vs. KC with PD. Has sack in 2 of his past 3 international games. • LB TULI TUIPULOTU led team with career-high 8.5 sacks & 11 TFL in 2024. • LB DAIYAN HENLEY led team with career-best 142 tackles last season, • S DERWIN JAMES had 7 PD & set career highs in TFL (10) & sacks (5.5) in 2024 & is only player in NFL with 5+ PD & 5+ TFL in each of past 4 seasons. Had sack in last meeting. • CB TARHEEB STILL led team & ranked tied-2nd among rookies with 4 INTs last season. • CB DONTE JACKSON makes LAC debut after career-high 5 INTs in 2024 with Pit
Game Odds
Kansas City Chiefs – 3
Los Angeles Chargers 44.5
Odds Courtesy of Sports Odd Direct as of Thursday, September 4, 2025
