MLB Game Preview: Chicago Cubs (66-49) vs. St. Louis Cardinals (59-58)

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St. Louis Cardinals logo

Game Overview

  • First Pitch: 7:15 p.m. ET / 6:15 p.m. CT
  • Venue: Busch Stadium, St. Louis
  • Series Status: Cardinals lead 1–0 in the current 3-game set
  • Season Series: Tied 4–4

Pitching Probables

TeamPitcherRecordERAWHIPStrikeouts
CubsColin Rea8–54.231.3279
CardinalsAndre Pallante6–84.571.3180
  • Rea has struggled against left-handed hitters (.305 AVG, 5.66 FIP)
  • Pallante enters in solid form (2 ER over last 12 IP)

Key Players to Watch

Chicago Cubs

  • Seiya Suzuki: 27 HR, 84 RBI
  • Nico Hoerner: .292 AVG, 12-for-37 last 10 games
  • Kyle Tucker: 18 HR, .271 AVG

St. Louis Cardinals

  • Lars Nootbaar: 3-game hit streak, strong splits vs. RHP
  • Brendan Donovan: .278 AVG, 24 doubles
  • Willson Contreras: 16 HR, 64 RBI

Team Trends & Stats

TeamLast 10 GamesBatting AVGERARun Diff
Cubs4–6.2264.03–6
Cardinals5–5.2453.83–3
  • Cubs rank 3rd in MLB in slugging (.437)
  • Cardinals are 32–14 when not allowing a home run

Injury Report

Cubs: Soroka, Amaya, Taillon, Morgan, Assad, Steele (all IL) Cardinals: Arenado, King, Thompson (all IL)

Final Take

The Cubs are favored but enter with offensive concerns, having scored just 3 runs in their last 3 losses. The Cardinals, meanwhile, are riding momentum after a 5–0 shutout win and have favorable matchups against Rea’s splits. Expect a tight contest with potential value on the under and player props like Lars Nootbaar’s H+R+RBI.

Game Odds

Chicago Cubs                     – 112

St. Louis Cardinals           9

Odds Courtesy of Sports Odd Direct as of Friday, August 8, 2025