The Houston Astros (59–42) and Arizona Diamondbacks (50–52) wrap up their three-game interleague series on Wednesday, July 23, 2025, at Chase Field in Phoenix, Arizona. First pitch is scheduled for 3:40 PM ET, with the Astros aiming for a series sweep after back-to-back wins, including a 3–1 victory on Tuesday.
Matchup Overview
- Venue: Chase Field, Phoenix, AZ
- Date: Wednesday, July 23, 2025
- Time: 3:40 PM ET
- Broadcast: SCHN (Astros), ARID (D-backs), MLB Network
- Streaming: MLB.TV, FuboTV (regional restrictions may apply)
Starting Pitchers
| Team | Pitcher | Record | ERA | WHIP | Strikeouts |
|---|---|---|---|---|---|
| Astros | Brandon Walter (LHP) | 1–3 | 3.66 | 1.28 | 25 |
| D-backs | Brandon Pfaadt (RHP) | 10–6 | 4.82 | 1.31 | 90 |
- Brandon Walter has allowed 15 earned runs in 28 road innings, but boasts a 25.2% strikeout rate and ranks in the 79th percentile for whiffs.
- Brandon Pfaadt has pitched well at home, averaging 91.6 adjusted pitches per start, and benefits from a platoon advantage against Houston’s right-heavy lineup.
Key Players to Watch
Houston Astros
- Jose Altuve: .280 AVG, 17 HR, 53 RBI – batting .365 in July with a 1.123 OPS; cleared 1.5 total bases in 7 of last 10 games.
- Brice Matthews: Rookie sensation with 3 HR and 7 RBI in the series; hit a two-run blast Tuesday and owns a 50% barrel rate over the past week.
- Christian Walker: .339 AVG in July; 2+ total bases in 5 of last 10 games.
Arizona Diamondbacks
- Eugenio Suárez: 36 HR, 85 RBI – homered in 5 of last 7 games; ranks 12th in MLB in home run skill.
- Ketel Marte: .299 AVG, 19 HR – projected to bat leadoff; hitting from his strong side vs. Walter.
- Josh Naylor: .270 AVG, 13 HR – hitting .417 over last 3 games; ranks in 88th percentile for batting average skill.
Team Stats & Trends
| Category | Astros | D-backs |
|---|---|---|
| Batting Average | .245 (last 10 games) | .271 (last 10 games) |
| Slugging Percentage | .394 | .445 |
| Home Runs | 100 (21st MLB) | 146 (3rd NL) |
| Runs Scored | 457 (12th MLB) | 432 (19th MLB) |
| Team ERA | 4.25 | 4.03 |
- Astros are 39–19 when recording 8+ hits and have covered in 4 of their last 5 road games.
- Diamondbacks are 26–27 at home and have hit the Over in 30 of their last 48 games.
Final Takeaway
The Astros vs. Diamondbacks matchup features two emerging starters and two lineups capable of explosive innings. With Jose Altuve, Brice Matthews, and Christian Walker swinging hot bats, and Eugenio Suárez and Ketel Marte anchoring Arizona’s offense, expect a high-scoring finale. Houston’s deeper bullpen and playoff urgency give them the edge, but Arizona’s power and home-field advantage could keep things close.
Game Odds
Houston Astros – 116
Arizona Diamondbacks 8.5
Odds Courtesy of Sports Odd Direct as of Tuesday, July 22, 2025
