MLB Game Preview: San Diego Padres (54-45) vs. Miami Marlins (46-52)

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Miami Marlins logo

Venue: loanDepot Park, Miami, FL
First Pitch: 6:40 PM ET
Watch Live: SDPA, FDSNFL, MLB.TV

Both teams opened the second half of the season with series wins, and this marks their second meeting of 2025 — San Diego took two of three in their May series, narrowly outscoring Miami 20–19.

The Padres are riding momentum from a dominant series against the Nationals, while the Marlins are fresh off a competitive set against the Royals. With two young starters on the mound, this opener promises a blend of power and finesse.

Starting Pitchers – July 21, 2025

TeamPitcherRecordERAWHIPK/9
PadresRandy Vásquez (RHP)3–43.801.395.3
MarlinsEury Pérez (RHP)3–23.180.919.3
  • Randy Vásquez has a 3.50 ERA over his last seven starts and pitched a quality outing against Miami in May, allowing 3 ER over 6.1 IP.
  • Eury Pérez is emerging as Miami’s ace, coming off a 7-inning shutout vs. Baltimore with 6 strikeouts and no walks. Opponents are hitting just .168 against him this season.

Players to Watch

San Diego Padres

  • Manny Machado: .288 AVG, 18 HR, 60 RBI; ranks top 30 in MLB for both HR and RBI
  • Fernando Tatis Jr.: .264 AVG, 16 HR, 54 walks; elite plate discipline and power
  • Xander Bogaerts: .267 AVG, 20 doubles, 6 HR; consistent contributor
  • Luis Arraez: .284 AVG, 17 doubles, 4 triples; contact specialist

Miami Marlins

  • Kyle Stowers: .295 AVG, 21 HR, 59 RBI; team leader in all major offensive categories
  • Otto Lopez: .250 AVG, 11 HR, 11 doubles; riding a five-game hit streak
  • Xavier Edwards: .286 AVG, 15 doubles, 2 triples; hitting .318 over last five games
  • Agustin Ramirez: .244 AVG, 14 HR, 21 doubles; emerging power bat

Team Comparison – Key Stats

CategoryPadresMarlins
Batting Avg.247 (16th MLB).253 (9th MLB)
Slugging %.377 (24th MLB).392 (18th MLB)
Home Runs86 (27th MLB)90 (26th MLB)
Runs/Game4.04.3
Team ERA3.13 (Top 5 MLB)3.27
Last 10 Games6–46–4

San Diego’s bullpen ranks 2nd in MLB ERA (3.19), while Miami’s relievers sit 19th at 4.03. The Padres have the edge in pitching depth, but the Marlins’ lineup has been hotter in July.

Game Odds

San Diego Padres             8.5

Miami Marlins                  – 135

Odds Courtesy of Sports Odd Direct as of Sunday, July 20, 2025