MLB Game Preview: Arizona Diamondbacks (41-38) vs. Chicago White Sox (25-55)

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Game Details

  • Matchup: Arizona Diamondbacks (41–38) vs Chicago White Sox (25–55)
  • Date: Wednesday, June 25, 2025
  • First Pitch: 2:10 PM ET
  • Venue: Guaranteed Rate Field, Chicago, IL
  • Broadcast: MLB.TV, Bally Sports Arizona, NBC Sports Chicago

Game Context & Series Recap

The Diamondbacks have taken the first two games of this three-game interleague series, winning 10–0 on Monday and 4–1 on Tuesday. Arizona is riding a wave of momentum, having won six straight series and looking to cap off a successful nine-game road trip.

The White Sox, meanwhile, are mired in a deep slump, having lost 11 of their last 13 games. They’ve struggled offensively, managing just four total runs in the first two games of the series.

Probable Pitchers

Arizona Diamondbacks: Zac Gallen (5–8, 5.60 ERA)

  • Coming off a shaky outing vs. Colorado (5 IP, 7 ER), but earned the win
  • Has 1 career start vs. White Sox: 7 shutout innings with 9 strikeouts (2019)
  • Needs to limit long balls (allowed 2 HR in last start)

Chicago White Sox: Sean Burke (3–7, 4.50 ERA)

  • Rookie right-hander with flashes of brilliance
  • 2.73 ERA in May, but 5.63 ERA in June
  • Coming off a solid outing vs. St. Louis (5.1 IP, 1 ER, 7 K)

Players to Watch

Arizona Diamondbacks

  • Ketel Marte: Batting .320 with 15 HR and 32 RBI; homered in back-to-back games
  • Josh Naylor: .303 AVG, 9 HR, 18 doubles; returned from shoulder soreness
  • Jake McCarthy: Recalled from Triple-A; hitting .370 over last 16 minor league games

Chicago White Sox

  • Miguel Vargas: Team leader with 10 HR and 34 RBI; .243 AVG
  • Lenyn Sosa: .269 AVG, 4 HR, 17 RBI; 2 multi-hit games in last 6
  • Andrew Benintendi: 8 HR, .239 AVG; needs to spark stagnant offense

Team Stats & Trends

CategoryDiamondbacksWhite Sox
Record41–3825–55
Runs/Game (Last 10)5.53.3
Team ERA (Last 10)4.554.74
Batting Average (L10).262.201
Run Line Record (2025)40–31 (equal rest)29–24 (as underdog)

Arizona is 11–6 against the run line in interleague games and 6–4 in their last 10 overall.

Arizona’s offense is clicking, and Gallen should bounce back against a struggling Chicago lineup. Burke may keep it close early, but the D-backs’ depth and bullpen edge give them the sweep.

How to Watch Diamondbacks vs White Sox – June 25, 2025

  • TV: Bally Sports Arizona, NBC Sports Chicago
  • Streaming: MLB.TV, FuboTV (regional restrictions apply)
  • Radio: KMVP 98.7 FM (Arizona), WMVP 1000 AM (Chicago)

Game Odds

Arizona Diamondbacks – 149

Chicago White Sox          9

Odds Courtesy of Sports Odds Direct as of Tuesday, June 24, 2025