MLB Game Preview: St. Louis Cardinals (36-32) vs. Milwaukee Brewers (36-33)

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Matchday: Thursday, June 12, 2025
First Pitch: 7:40 PM ET
Venue: American Family Field, Milwaukee, WI
Broadcast: Bally Sports Midwest, Bally Sports Wisconsin, MLB.TV

Overview: Cardinals vs. Brewers – NL Central Rivalry

The St. Louis Cardinals (36-32) and Milwaukee Brewers (36-33) face off in the first game of a pivotal four-game series at American Family Field. Both teams are battling for position in the NL Central standings, with the Cardinals looking to snap a four-game losing streak and the Brewers aiming to build momentum after a recent 5-5 stretch.

St. Louis has struggled on the road, holding a 14-18 away record, while Milwaukee has been solid at home, boasting a 20-14 record at American Family Field.

St. Louis Cardinals: Seeking a Turnaround

The Cardinals enter this matchup needing a win after dropping four straight games. Their offense has been inconsistent, but Brendan Donovan has been a bright spot, leading the team with a .310 batting average.

Key Players to Watch:

  • Brendan Donovan – .310 AVG, ranks 11th in MLB in batting average
  • Nolan Arenado – 8 HR, 35 RBI; looking to extend his two-game hit streak
  • Willson Contreras – .333 AVG in his last five games, with two doubles and a home run

Starting Pitcher:

  • Sonny Gray (7-1, 3.35 ERA, 81 K) – Coming off a scoreless 6.1-inning performance against the Dodgers

Injury Report:

  • Out: Christian Yelich (day-to-day, wrist), Connor Thomas (elbow), Blake Perkins (shin), Garrett Mitchell (oblique)

Milwaukee Brewers: Home Field Advantage

The Brewers have been competitive but inconsistent, going 5-5 in their last 10 games. Their pitching staff ranks 8th in the NL with a 3.87 ERA, but their offense has struggled, ranking 23rd in MLB in batting average.

Key Players to Watch:

  • Christian Yelich – 13 HR, 41 RBI; leads Brewers in power hitting
  • Jackson Chourio – 11 HR, 39 RBI; emerging as a key offensive contributor
  • Sal Frelick – .284 AVG; leads Brewers in batting average

Starting Pitcher:

  • Jacob Misiorowski (0-0, MLB debut) – Making his first career start

Injury Report:

  • Out: Nestor Cortes (elbow), Brandon Woodruff (shoulder), Robert Gasser (elbow)

Head-to-Head: Cardinals vs. Brewers

  • Season Series: First meeting of 2025
  • Last Meeting: Cardinals won 2-1 (September 2024)
  • At American Family Field: Brewers are 20-14 at home this season

Tactical Breakdown & Prediction

The Cardinals will look to capitalize on Gray’s strong pitching and rely on Arenado and Contreras to spark their offense. The Brewers, meanwhile, must support Misiorowski in his MLB debut and find ways to generate runs against Gray’s dominant pitching.

Game Odds

St. Louis Cardinals           – 138

Milwaukee Brewers       7.5

Odds Courtesy of Sports Odds Direct as of Wednesday, June 11, 2025