MLB Game Preview: Arizona Diamondbacks (26-26) vs. St. Louis Cardinals (29-23)

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St. Louis Cardinals logo

The Arizona Diamondbacks and St. Louis Cardinals face off in the second game of a three-game series at Busch Stadium on Sunday, May 25, 2025. The Cardinals enter as -125 moneyline favorites, while the Diamondbacks look to bounce back after a three-game losing streak.

Game Details

  • Date: Sunday, May 25, 2025
  • Time: 2:15 PM ET
  • Location: Busch Stadium, St. Louis, MO
  • TV Broadcast: FDSMW, ARID

Team Form & Key Matchups

Arizona Diamondbacks (26-25, 4th in NL West)

  • Recent Performance: The Diamondbacks have lost four straight games, including a 5-6 loss to St. Louis in Game 1 of the series.
  • Key Players:
    • Corbin Carroll15 HR, ranks 5th in MLB in home runs
    • Geraldo Perdomo.299 BA, leading Arizona in batting average
    • Josh Naylor.289 BA, 12 doubles, 5 HR
  • Strengths: Power hitting, aggressive baserunning
  • Concerns: Pitching struggles, bullpen inconsistency

St. Louis Cardinals (28-23, 2nd in NL Central)

  • Recent Performance: The Cardinals have won three of their last five games, including a 6-5 victory over Arizona in Game 1.
  • Key Players:
    • Lars Nootbaar7 HR, 25 RBI, leading the team in home runs
    • Brendan Donovan.321 BA, best batting average on the team
    • Victor Scott II.283 BA, riding a four-game hitting streak
  • Strengths: Strong lineup depth, clutch hitting
  • Concerns: Middle relief inconsistencies

Starting Pitchers

Arizona Diamondbacks – Brandon Pfaadt (7-3, 3.81 ERA, 1.24 WHIP)

  • Last Start: 6.0 IP, 4 ER, 6 H vs. Los Angeles Dodgers
  • Strengths: Solid fastball, effective against right-handed hitters
  • Concerns: Occasional struggles with command

St. Louis Cardinals – Sonny Gray (5-1, 4.02 ERA, 1.13 WHIP)

  • Last Start: 6.0 IP, 0 ER, 3 H vs. Detroit Tigers
  • Strengths: High strikeout rate (9.8 K/9), excellent control
  • Concerns: Inconsistent performances

Tactical Breakdown

  • Diamondbacks’ Strategy: Arizona must capitalize on Gray’s weaknesses, relying on Carroll and Perdomo to drive in runs.
  • Cardinals’ Strategy: St. Louis will look to Nootbaar and Donovan to generate offense while Gray controls the tempo.

Game Odds

Arizona Diamondbacks                 7.5

St. Louis Cardinals                           – 125

Odds Courtesy of Sports Odds Direct as of Saturday, May 24, 2025