MLB Game Preview: Chicago White Sox (14-32) vs. Chicago Cubs (27-19)

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The Chicago White Sox (14-32) will face the Chicago Cubs (27-19) in the final game of their three-game series at Wrigley Field. First pitch is set for 2:20 PM ET, with the Cubs looking to complete the series sweep after dominant wins in the first two games.

Game Details

  • Matchup: Chicago White Sox vs. Chicago Cubs
  • Date: Sunday, May 18, 2025
  • Location: Wrigley Field, Chicago, IL
  • Time: 2:20 PM ET
  • TV Broadcast: Marquee Sports Network, NBC Sports Chicago
  • Streaming: FuboTV, MLB.TV (regional restrictions apply)

Team Overview & Key Storylines

Chicago White Sox (14-32)

  • The White Sox have struggled this season, ranking second-worst in MLB with just five road wins in 25 games.
  • Miguel Vargas leads the team with five home runs and 19 RBIs, while Luis Robert Jr. has also contributed five homers.
  • Jonathan Cannon (2-4, 3.60 ERA) will start on the mound, looking to contain the Cubs’ explosive offense.
  • The White Sox have been outscored 20-6 in the first two games of the series, highlighting their struggles against their crosstown rivals.

Chicago Cubs (27-19)

  • The Cubs are first in the NL Central, boasting a 14-10 home record.
  • Seiya Suzuki has been heating up, recording 10 total bases in his last three games, including two home runs against the White Sox.
  • Colin Rea (3-0, 2.48 ERA) will take the mound, having helped the Cubs to a 5-1 record in his starts.
  • The Cubs have been dominant in this matchup, winning four of their last five games against the White Sox.

Key Matchups to Watch

  • Jonathan Cannon (White Sox) vs. Cubs’ Offense – Cannon has allowed six or more hits in each of his last four starts, which could be problematic against Chicago’s powerful lineup.
  • Seiya Suzuki vs. White Sox Pitching – Suzuki has been on fire, going over 1.5 total bases in three straight games.
  • Kyle Tucker vs. Miguel Vargas – Both players lead their teams in home runs and could be key offensive contributors.

Game Odds

Chicago White Sox          7.5

Chicago Cubs                     – 270

Odds Courtesy of Sports Odds Direct as of Saturday, May 17, 2025

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