NFL Game Preview: Los Angeles Chargers (0-5-0) vs. Kansas City Chiefs (4-0-0)

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Kansas City Chiefs logo

CBS: Kevin Harlan, Trent Green, Melanie Collins (field reporter)

Kickoff is scheduled for 4:25 PM ET

Arrowhead Stadium

Referee: Alan Eck

Regular Season: KC leads series, 71-59-1 (LAC won past 2)

Last reg. season meeting: 12/14/25: LAC 16 at KC 13

Jim Harbaugh (LAC) vs. Opp. (incl. postseason): 3-2 Reg. Season: 66-36-1 (.646)

Andy Reid (KC) vs. Opp. (incl. postseason): 21-8 Reg. Season: 283-157-1 (.643)

LA Chargers Last Game: L, 23-17 vs. DEN (Week 5)

Kansas City Last Game: W, 30-27 at LV (Week 4)

CHARGERS NOTES

• QB JUSTIN HERBERT passed for 121 yards & TD & had season-high 54 rush yards in Week 5. Ranks 3rd in completions (2,370), 4th in pass yards (25,757) & tied6th in TD passes (168) since 2020. Aims for his 5th in row on road with TD pass. Completed 19 of 29 atts. (65.5 pct.) for 210 yards & TD pass in last meeting. • RB KIMANI VIDAL led team with 57 rush yards & had rush TD last week. Aims for his 3rd in row with TD. Had 48 scrimmage yards (33 rush, 15 rec.) in last meeting. • RB OMARION HAMPTON aims for his 6th in row on road with 50+ scrimmage yards. Has rush TD in 2 of his past 3 on road. Had 65 scrimmage yards (61 rush, 4 rec.) in last meeting. • WR QUENTIN JOHNSTON aims for his 4th in row on road with 40+ rec. yards & aims for his 3rd in row vs. KC with 5+ catches & rec. TD. Had 5 receptions for 79 yards & 2 rec. TDs in his last game vs. KC (9/5/25). • WR MARQUEZ VALDES-SCANTLING spent 2022-23 with KC, totaling 63 receptions for 1,002 yards & 3 TDs & won SB LVII & LVIII. • TE HAYDEN RUCCI had 1st-career rec. TD in Week 5. • LB KHALIL MACK has TFL in 5 of his past 6 & has sack in 3 of his past 4. Ranks 2nd in NFL in TFL (153) & FFs (36), tied-3rd in FRs (13) & 4th in sacks (116) since 2014. Had sack in last meeting. • LB DAIYAN HENLEY had 6 tackles & PD in Week 5. Had INT in last meeting. • LB TULI TUIPULOTU had FF, FR & PD last week. Aims for his 3rd in row with FF & PD. Had 3 TFL & 2 sacks in last meeting. • LB AKHEEM MESIDOR (rookie) led team with career-high 8 tackles & had sack & 1st-career FF in Week 5. Ranks 2nd among rookies in sacks (2.5) this season. Has 0.5+ sacks in 3 of his past 4. • CB TARHEEB STILL had 5 tackles & PD last week. Aims for his 3rd in row with PD. • DB ELIJAH MOLDEN had 7 tackles in Week 5. Aims for his 4th in row with 5+ tackles. • S DERWIN JAMES had 10 tackles, 2 PD & INT in last meeting.

CHIEFS NOTES

• QB PATRICK MAHOMES passed for 225 yards & 2 TDs in Week 4. Is 1 of 2 AFC QBs (Kirk Cousins) with 2+ TD passes in 4 games this season. Aims for his 4th in row with 225+ pass yards & 2+ TD passes. Is 10-4 vs. LAC, totaling 3,717 pass yards (265.5 yards/game) & 30 TDs (28 pass, 2 rush). Passed for 189 yards & had rush TD in last meeting. • RB KENNETH WALKER led team with career-high 177 rush yards & had 2 rush TDs in Week 4, becoming 2nd player ever (Billy Sims) with 175+ scrimmage yards in 3 of his 1st 4 games with a franchise. Is 1 of 4 players with 2+ scrimmage TDs in 3 games this season. Has 110+ scrimmage yards in 7 of his past 8, incl. playoffs. Had 167 rush yards & 2 rush TDs in his only career game vs. LAC (10/23/22 w/ Sea.). • WR RASHEE RICE has 80+ rec. yards in 2 of his past 3. Has 5+ catches & 50+ rec. yards in 2 of his 3 career games vs. LAC, incl. 7 receptions for 51 yards in last meeting. • TE TRAVIS KELCE needs 5 receptions to tie HOFer Cris Carter (1,101) for 6thmost receptions in NFL history. Has 5+ catches in 9 of his past 10 vs. LAC & has rec. TD in 2 of his past 3 overall. Had 7 catches for 70 yards in last meeting. • DT CHRIS JONES had 1st TFL of season & PD in Week 4. Aims for his 3rd in row with PD. • DE GEORGE KARLAFTIS had 5 tackles, TFL & PD in Week 4. Aims for his 3rd in row with TFL & PD. Had TFL in both meetings in 2025. • LB NICK BOLTON had 9 tackles in Week 4. Has 10+ tackles & TFL in 2 of his past 3. Had 11 tackles & TFL in last meeting. • LB DRUE TRANQUILL had 7 tackles, 2 TFL & PD in Week 4. Spent 1st 4 seasons with LAC, totaling 279 tackles, 19 TFL, 6.5 sacks, 6 PD, FF, FR & INT. Had 14 tackles & TFL in last meeting. • CB MANSOOR DELANE had 10 tackles, TFL & PD in Week 4 & is 1 of 4 rookies with 10+ tackles in 2+ games (2) this season

Game Odds

Los Angeles Chargers     41.5

Kansas City Chiefs           – 7.5

Odds Courtesy of Sports Odd Direct as of Saturday, October 17, 2026

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