Week 6 NFL Preview

NEW YORK – This season, 24 games have featured a game-winning score in the final five minutes of the fourth quarter or in overtime, tied for the third-most such games through Week 5 in NFL history. Three teams – Kansas City (4-0), Minnesota (5-0, Week 6 bye) and San Francisco (5-0) – remain undefeated while eight teams that missed the postseason in 2025 have a winning record through the first five weeks.

Here’s a look at a few interesting storylines entering Week 6:

• Washington (1-3-1) at San Francisco (5-0) (Monday night, 8:15 p.m. ET, ESPN/ABC): The 49ers can win each of their first six games of a season for the fourth time in franchise history (1984, 1990 and 2019).
  • San Francisco quarterback Brock Purdy leads the NFL with 13 touchdown passes and ranks second among qualified passers with a 119.3 rating this season. In Week 6, he can become the first quarterback since 2018 (Philip Rivers) with multiple touchdown passes and a passer rating of 90-or-higher in each of his team’s first six games of a season.
  • 49ers linebacker Fred Warner recorded his 20th career forced fumble last week and is one of three players under the age of 30 with at least 20 forced fumbles and 10 interceptions since 2000, joining Lavonte David and Charles Tillman.
  • Washington quarterback Jayden Daniels recorded rushing touchdowns of 38 and 26 yards in Week 5 and became the second quarterback since 1950 with multiple rushing touchdowns of 25-or-more yards in the same game, joining Mike Vick (Dec. 1, 2002).
    
• Los Angeles Chargers (0-5) at Kansas City (4-0) (4:25 p.m. ET, CBS): The Chiefs, coming off a Week 5 bye, can begin 5-0 for the fifth time since head coach Andy Reid was hired in 2013. Reid, who also led Philadelphia to a 5-0 start in 2004, can become the third head coach all-time to lead a team to a 5-0 start in six seasons, joining Pro Football Hall of Famers George Halas (10 seasons) and Paul Brown (six).
  • Kansas City running back Kenneth Walker has 621 scrimmage yards and six touchdowns this season and is one of two players in NFL history with at least 175 scrimmage yards in three of his first four games with a franchise, joining Billy Sims (1980 with Detroit). In Week 6, he can become the first running back in 60 seasons (Emerson Boozer, 1967 with the New York Jets) with multiple touchdowns in four of his team’s first five games of a season.
    
• Seattle (3-2) at Denver (3-2) (Thursday night, 8:15 p.m. ET, Prime Video): Since the beginning of the 2024 season, the Seahawks have the highest road winning percentage (.842; 16-3) in the NFL while the Broncos have the second-highest home winning percentage (.842; 16-3) during that span.
  • Seattle wide receiver Jaxon Smith-Njigba leads the NFL with 583 receiving yards and seven touchdown receptions entering Week 6. Last week, he became the fourth player in NFL history with at least 100 receiving yards and a touchdown reception in four of his team’s first five games of a season, joining Pro Football Hall of Famers Elroy “Crazylegs” Hirsch (1951 with the Los Angeles Rams), Randy Moss (2007 with New England) and Jerry Rice (1989 with San Francisco).
  • Denver quarterback Bo Nix led the Broncos to 13 unanswered points in the fourth quarter last week in the team’s 23-17 win at the Los Angeles Chargers. Nix has 13 career game-winning drives in the fourth quarter or overtime, tied with Justin Herbert and Matt Ryan for the second-most by a player in his first three seasons since 1970. Only Dak Prescott (14 game-winning drives) has more.
    
• Houston (1-4) vs. Jacksonville (4-1) (London, 9:30 a.m. ET, NFL Network): For the third consecutive week, the NFL will play a regular season game in London as the Texans and Jaguars meet at Wembley Stadium. Jacksonville defeated Philadelphia, 19-17, at Tottenham Hotspur Stadium in London last week while Houston earned their first win of the season with a 26-3 win at Tennessee.
  • The Jaguars lead the NFL in rushing defense this season (63.8 yards per game allowed) and became the second team in the Super Bowl era to not allow an opposing player to rush for 40-or-more yards in their first five games of a season, joining the 1969 Dallas Cowboys.
  • This week, Jacksonville can tie the 1998-2000 Baltimore Ravens (23 consecutive games) for the third-longest streak of consecutive games without allowing an opposing player to rush for 75-or-more yards in the Super Bowl era.
  • Houston defensive end Will Anderson leads the NFL with 7.5 sacks and 10 tackles for loss this season and is one of three players with at least 7.5 sacks and 10 tackles for loss in his team’s first five games of a season since 2000, joining Clay Matthews (2010 with Green Bay) and J.J. Watt (2012 with Houston).
    
• Buffalo (4-1) at Las Vegas (3-2) (4:25 p.m. ET, CBS): Last week, Bills quarterback Josh Allen became the fourth quarterback all-time with at least 100 wins, including the postseason, in his first nine career seasons, joining Patrick Mahomes (112), Russell Wilson (107) and Tom Brady (101). Allen totaled 331 yards (210 passing, 121 rushing) and two touchdowns (one passing, one rushing) in the win, becoming the first quarterback ever with a rushing touchdown in each of his team’s first five games of a season.
  • Raiders tight end Brock Bowers is one of two tight ends in NFL history with at least 80 receiving yards and a touchdown reception in each of his first three games of a season, joining Rob Gronkowski (2011 with New England). This week, he can become the fifth tight end ever with five receptions, including a touchdown catch, in five consecutive games, joining Pro Football Hall of Famers Tony Gonzalez (six from 2008-09) and Antonio Gates (five in 2010) as well as Travis Kelce (six from 2020-21) and Trey McBride (five in 2025).
    
• New York Jets (2-3) at New England (3-2) (1 p.m. ET, CBS): Last week, the Jets recorded eight sacks, the most by any team in a game this season, in the team’s 17-12 victory over Cleveland, including three sacks by rookie EDGE David Bailey. Bailey is one of three players in the last 24 seasons (2003-26) to record three sacks in a game within his first five career games, joining Aidan Hutchinson (three sacks on Sept. 18, 2022 with Detroit) and Elvis Dumervil (three sacks on Oct. 22, 2006 with Denver).
  • In Week 5, New England quarterback Drake Maye became the youngest player ever (24 years, 42 days) and the fourth player all-time with at least 350 passing yards (374), four touchdown passes, a passer rating of 150-or-higher (150.9) and a rushing touchdown in a single game, joining Pro Football Hall of Famer Drew Brees (Dec. 29, 2013 with New Orleans), Ryan Fitzpatrick (Sept. 9, 2018 with Tampa Bay) and Aaron Rodgers (Oct. 20, 2019 with Green Bay).

• Baltimore (4-1) at Cleveland (3-2) (1 p.m. ET, FOX): The Ravens and Browns are two of eight teams with at least three wins in 2026 that missed the playoffs last season. Cleveland can win each of its first three home games for the third time since 1999 (2004 and 2020) while Baltimore can win each of its first four road games for the second time in franchise history (2020).
  • Baltimore’s Derrick Henry can become the third running back age 32-or-older with a touchdown in each of his team’s first six games of a season, joining Pro Football Hall of Famers Walter Payton (1986 with Chicago) and John Riggins (1983 and 1984 with Washington).
  • Cleveland’s Denzel Boston leads all rookies with 330 receiving yards and leads the NFL with 20.6 yards per reception this season (minimum 10 catches). He is one of five players in the Super Bowl era to record a reception of 25-or-more yards in each of his first five career games, joining Ja’Marr Chase (2021 with Cincinnati), Stefon Diggs (2015 with Minnesota), CeeDee Lamb (2020 with Dallas) and Earl McCullouch (1968 with Detroit).
    
• Dallas (2-3) at Green Bay (3-2) (Sunday night, 8:20 p.m. ET, NBC): Last week, Packers wide receivers Christian Watson (six receptions for 143 yards and two touchdowns) and Matthew Golden (six receptions for 123 yards) became the fourth pair of teammates to each average 20-or-more yards per catch on six-or-more receptions in the same game since 2000, joining San Francisco’s Brandon Aiyuk and Deebo Samuel (Dec. 10, 2023), Arizona’s Anquan Boldin and Pro Football Hall of Famer Larry Fitzgerald (Sept. 14, 2008) and Indianapolis’ Reggie Wayne and Pro Football Hall of Famer Marvin Harrison (Nov. 10, 2002).
  • Watson (26 for 474; 18.2) and Golden (24 receptions for 397 yards; 16.5) are one of four pairs of wide receiver teammates to average at least 16 yards per catch on 20-or-more receptions in their team’s first five games of a season since 2000, joining Dallas’ Amari Cooper and Michael Gallup in 2019, Green Bay’s James Jones and Jordy Nelson in 2013, the St. Louis Rams’ Torry Holt and Pro Football Hall of Famer Isaac Bruce in 2000.