ESPN/ABC: Joe Buck, Troy Aikman, Lisa Salters (field reporter), Laura Rutledge (field reporter)
Westwood One: Ryan Radtke, Mike Golic
Kickoff is scheduled for 8:15 PM ET
SoFi Stadium | Referee: Scott Novak
Regular Season: BUF leads series, 9-6 (BUF won 3 of past 4)
Last reg. season meeting: 12/8/24: BUF 42 at LAR 44
Joe Brady (BUF) vs. Opp. (incl. postseason): 0-0 Reg. Season: 3-1 (.750)
Sean McVay (LAR) vs. Opp. (incl. postseason): 1-2 Reg. Season: 94-59 (.614)
Buffalo Last Game: L, 29-26 vs. NE (Week 4)
LA Rams Last Game: W, 24-20 at PHI (Week 4)
BILLS NOTES
• QB JOSH ALLEN completed 23 of 33 atts. (69.7 pct.) for 253 yards & TD & had rush TD in Week 4. Needs win to become 4th QB ever with 100+ wins, incl. playoffs, in 1st nine seasons & can tie HOFer Peyton Manning (92) for 3rdmost reg. season wins by starting QB in 1st 9 seasons in NFL history. Aims for his 5th in row overall with 200+ pass yards & rush TD & 4th in row on MNF with 2+ TD passes. Passed for 342 yards & 3 TDs with 117.2 rating & rushed for 82 yards & 3 TDs in last meeting. • RB JAMES COOK had 83 scrimmage yards (75 rush, 8 rec.) & rush TD last week. Ranks 3rd in NFL with 421 rush yards in 2026. Aims for his 4th in row overall with rush TD & 3rd in row in primetime with 125+ scrimmage yards & rush TD. • WR KEON COLEMAN had 6 receptions for 116 yards & TD in Week 4. Has 6+ receptions in 2 of his past 3. • WR KHALIL SHAKIR had 7 receptions for 82 yards last week. Has 50+ rec. yards in 2 of his past 3 on road. Had 5 catches for 106 yards & rec. TD in last meeting. • WR DJ MOORE aims for his 5th in row on MNF with 50+ scrimmage yards & 3rd in row vs. LAR, incl. playoffs, with rec. TD. • LB GREG ROUSSEAU had 4 tackles & 2 PD in Week 4. Has 0.5+ sacks in 6 of his past 7. Aims for his 4th in row on road with sack. Leads NFL with 6 sacks in 2026. • LB DORIAN WILLIAMS led team with 8 tackles & had TFL last week. Has 6+ tackles & TFL in 4 of his past 5. • LB TERREL BERNARD had 7 tackles in Week 4. Aims for his 5th in row with 5+ tackles. • LB TJ PARKER (rookie) had 1st career FF & 1st career 0.5 sack last week. • LB BRADLEY CHUBB had 4 tackles & TFL last week. • DL ED OLIVER has sack in 3 of his past 4 on road. • CB DEE ALFORD had 5th-career INT last week. • S COLE BISHOP had 7 tackles in Week 4. Aims for his 5th in row with 5+ tackles. • G/C AUSTIN CORBETT, DL GREG GAINES & LB MICHAEL HOECHT won SB LVI with LAR in 2021
RAMS NOTES
• QB MATTHEW STAFFORD passed for 317 yards in Week 4. Is 1st player in NFL history with 20,000+ pass yards with 2 teams (LAR & Det.). Aims for 4th in row with 315+ pass yards. Has 2+ TD passes in 6 of his past 7 on primetime. Aims for 5th in row vs. Buf. with TD pass. • RB KYREN WILLIAMS had 147 scrimmage yards (80 rush, 67 rec.) & 2 rush TDs in Week 4. Ranks 5th among RBs with 467 scrimmage yards (294 rush, 173 rec.) this season. Had 87 rush yards & 2 rush TDs in last meeting. Has 95+ scrimmage yards in 3 of his past 4 on primetime. • WR DAVANTE ADAMS has 390 rec. yards in 2026. Aims for 3rd in row on primetime with 130+ rec. yards. Ranks 3rd with 13,023 career rec. yards since 2014. Needs 2 rec. TDs to tie HOFer Larry Fitzgerald (121) for 6th-most alltime. • WR PUKA NACUA led team with 125 rec. yards in Week 4. Ranks 4th with 4,390 rec. yards since 2023. Aims for 4th in row with 70+ rec. yards. Has TD catch in 2 of his past 3 on primetime. Had 12 receptions for 162 yards & TD catch & had rush TD in last meeting. • TE TYLER HIGBEE had 5 catches for 67 yards in Week 4. Aims for 3rd in row with 60+ rec. yards. • DE AARON DONALD ranks tied-2nd among active players with 177 TFL. • DE KOBIE TURNER had PD in Week 3. Aims for 3rd in row with PD. • LB BYRON YOUNG had 6 tackles, 2.5 sacks & FF in Week 4. Has sack in 2 of his past 3. • LB NATE LANDMAN led team with 9 tackles in Week 4. Has 6+ tackles in 3 of his past 4 on primetime. • LB OMAR SPEIGHTS had sack in Week 4 & aims for 3rd in row with sack. • CB TRENT MCDUFFIE & S QUENTIN LAKE rank tied-1st with 7 PD each in 2026. • S KAMREN KINCHENS had 6 tackles, 0.5 sacks & PD in Week 4.
Game Odds
Buffalo Bills 54.5
Los Angeles Rams – 3.5
Odds Courtesy of Sports Odd Direct as of Sunday, October 11, 2026
