SoFi Stadium | Referee: Ron Torbert
Kickoff is scheduled for 4:25 PM ET
CBS: Kevin Harlan, Trent Green, Melanie Collins (field reporter)
Regular Season: LAC leads series, 11-5 (LAC won past 2 of past 3)
Last meeting: 10/21/24: LAC 15 at ARI 17
Mike LaFleur (ARI) vs. Opp. (incl. postseason): 0-0 Reg. Season: 0-0
Jim Harbaugh (LAC) vs. Opp. (incl. postseason): 6-3 Reg. Season: 66-31-1 (.679)
CARDINALS NOTES
• QB JACOBY BRISSETT set career-highs with 3,366 pass yards & 23 TD passes in 2025 & had 94.1 rating. Had 200+ pass yards & TD in all 12 starts last season. Ranked 2nd with 3,366 pass yards as starting QB from Weeks 6-18. Has TD pass in 2 of his past 3 games vs. LAC (w/ Ind., Cle., NE). • RB JEREMIYAH LOVE can make NFL debut after being selected No. 3 overall in 2026 NFL Draft. • RB TYLER ALLGEIER recorded career-high 8 rush TDs in 2025 w/ Atl. • WR MARVIN HARRISON JR. ranks 6th among qualified WRs (100+ receptions) with 14.5 yards per reception since entering NFL in 2024. • WR MICHAEL WILSON recorded career-high 78 receptions for 1,006 rec. yards & 7 TD catches in 2025. • TE TREY MCBRIDE had 126 receptions in 2025, most by TE in single season in NFL history. Became 1st TE all-time with 110+ receptions in multiple career seasons (111 catches in 2024). Has 347 career receptions, most by TE in his 1st 4 seasons in NFL history & can surpass Jimmy Graham (386) for most receptions by TE in his 1st 5 seasons all time. • ILB MACK WILSON had 60 tackles, 3 TFL, FF, 6 PD & INT in 2025. • OLB JOSH SWEAT ranked tied-5th among LBs with career-high 12 sacks in 2025 & had 13 TFL, 4 FF, FR & 2 PD. 1 of 4 LBs with 10+ sacks, FF & FR last season. • CB DENZEL BURKE co-led all rookies with 11 PD last season & had 3 INTs, 2ndmost among rookies. • S BUDDA BAKER leads all safeties with 1,003 tackles since entering NFL in 2017, 1 of 5 safeties since 2000 with at least 1,000 career tackles. Had 8+ tackles in 6 of his last 7 games in 2025. Aims for 3rd in row vs. LAC with 5+ tackles. • S DADRION TAYLOR-DEMERSON had career-high 6 PD & 2 INTs in 2025. Had 9+ tackles in 2 of his last 3 games last season.
CHARGERS NOTES
• CHARGERS have won 6 of past 7 Week 1 games. • HC JIM HARBAUGH is 6-0 in season-opening games. • QB JUSTIN HERBERT totaled 3,727 pass yards & 28 TDs (26 pass, 2 rush), becoming 3rd QB all-time with 3,000+ pass yards & 20+ TD passes in each of 1st 6 seasons. Surpassed HOFer Peyton Manning for most completions by QB in 1st 6 seasons in NFL history (2,285). Aims for his 4th in row with 65+ comp. pct., 210+ pass yards & TD pass. Completed 27 of 39 atts. (69.2 pct.) for 349 yards in last meeting. • RB OMARION HAMPTON totaled 737 scrimmage yards (545 rush, 192 rec.) & 5 scrimmage TDs (4 rush, 1 rec.) in 9 games as rookie last season. Has scrimmage TD in 3 of his past 4. • WR LADD MCCONKEY totaled 66 receptions for 789 yards & 6 TDs in 2025. • WR QUENTIN JOHNSTON totaled 51 receptions for 735 yards & 8 TDs last season, 2nd-consecutive season with 50+ receptions, 700+ rec. yards & 8+ rec. TDs. Aims for his 3rd in row with 95+ rec. yards. • TE DAVID NJOKU has 4,062 career rec. yards since 2017. Can make LAC debut. • LB KHALIL MACK totaled 32 tackles, 6 TFL, 5.5 sacks & 4 FFs in 2025. Is only player with 5+ sacks in each of past 11 seasons. Is 1 of 2 since 1982 (HOFer Kevin Greene) with 35+ sacks with 3+ teams. Has TFL in each of his 6 games at SoFi Stadium last season. Has TFL in 3 of his 4 career games vs. Ari. • LB TULI TUIPULOTU set career highs in sacks (13) & TFL (20) & had 45 tackles, 3 PD, 2 FFs & FR last season. Has sack in 3 of his past 4, incl. playoffs. • LB DAIYAN HENLEY totaled 101 tackles, 5 TFL, 5 PD & set career highs in sacks (3.5) & INTs (2) in 2025, 2nd-consecutive season with 100+ tackles. Aims for his 3rd in row, incl. playoffs, with 10+ tackles. Had 4 tackles & PD in last meeting. • S DERWIN JAMES totaled 94 tackles, 7 PD, 6 TFL, 3 INTs & 2 sacks in 2025. Has 8+ tackles & INT in 2 of his past 3. Had 8 tackles in last meeting.
Game Odds
Arizona Cardinals 47.5
Los Angeles Chargers – 10
Odds Courtesy of Sports Odd Direct as of Saturday, September 12, 2026
