Reliant Stadium | Referee: Alex Moore
Kickoff is scheduled for 1:00 PM ET
CBS: Ian Eagle, Ross Tucker, Evan Washburn (field reporter)
Regular Season: HOU leads series, 7-5 (home team won past 7)
Last meeting: 11/20/25: BUF 19 at HOU 23
Joe Brady (BUF) vs. Opp. (incl. postseason): 0-0 Reg. Season: 0-0
DeMeco Ryans (HOU) vs. Opp. (incl. postseason): 2-0 Reg. Season: 32-19 (.627)
BILLS NOTES
• QB JOSH ALLEN completed 319 of 460 atts. (career-high 69.3 pct.) for 3,668 yards & 25 TDs with 102.2 rating & rushed for 579 yards & 14 TDs in 2025. Became 1st player ever with 3,000+ pass yards, 20 TD passes & 10 rush TDs in 3 consecutive seasons & 3 career seasons. Surpassed Patrick Mahomes for most combined pass & rush yards by player in 1st 8 seasons all-time (34,823). Surpassed Cam Newton for most rush TDs by QB ever (79). • RB JAMES COOK ranked 1st in NFL with career-high 1,621 rush yards, 4th with career-high 1,912 scrimmage yards & had 14 scrimmage TDs (12 rush, 2 rec.) last season. Had 12 games with 100+ scrimmage yards, tied-most in NFL in 2025. Has 110+ scrimmage yards in 5 of his past 6 on road, incl. playoffs. Had 129 scrimmage yards (116 rush, 13 rec.) & rush TD in last meeting. • WR DJ MOORE can make Buf. debut after totaling 50 receptions for 682 yards & 6 TDs with Chi. in 2025. Aims for his 3rd in row vs. Hou. with 6+ receptions & 50+ rec. yards. • WR KHALIL SHAKIR led team in receptions (72) & rec. yards (719) & had 4 rec. TDs last season. Has 70+ receptions in each of past 2 seasons. Has 5+ receptions & 65+ rec. yards in 3 of his past 4 on road, incl. playoffs. Had 8 catches for 110 yards in last meeting. • TE DALTON KINCAID led team with career-high 5 rec. TDs & had 39 receptions for 571 yards in 12 games last season. Was 1 of 4 TEs with 2+ games of 5+ receptions & 100+ rec. yards in 2025 (2). • LB GREG ROUSSEAU led team with 7 sacks & had 46 tackles, 6 TFL, 2 PD & FF in 2025. Aims for his 4th in row with 0.5+ sack. Had 6 tackles in last meeting. • S C.J. GARDNER-JOHNSON can make Buf. debut after totaling 66 tackles, 5 TFL, 4 PD, career-high 3 sacks, 2 INT & FF with Hou. & Chi. in 2025. • S COLE BISHOP led team with career-high 85 tackles & set career highs in sacks (2), TFL (4), PD (7) & INTs (3) last season.
TEXANS NOTES
• QB C.J. STROUD totaled 3,041 pass yards & 20 TDs (19 pass, 1 rush) in 2025, 3rd-consecutive season with 3,000+ pass yards. Aims for his 8th in row, incl. playoffs, with TD pass. Completed 28 of 38 atts. (73.7 pct.) for 331 yards & TD vs. INT with 97.6 rating in only career game vs. Buf. (10/6/24). • RB DAVID MONTGOMERY can make Hou. debut after totaling 908 scrimmage yards (716 rush, 192 rec.) & 8 rush TDs with Det. last season. Is 1 of 3 RBs (Derrick Henry & Josh Jacobs) with 900+ scrimmage yards in each of past 7 seasons. • WR NICO COLLINS led team in rec. yards (1,117) & had 71 receptions & 6 rec. TDs last season, 3rd-consecutive season with 1,000+ rec. yards. Has 50+ rec. yards in 15 of his past 16 at home, incl. playoffs. • TE DALTON SCHULTZ led team with career-high 82 receptions & had 777 rec. yards & 3 rec. TDs last season. Is 1 of 2 TEs (Travis Kelce) with 50+ receptions & 500+ rec. yards in each of past 6 seasons. • DE WILL ANDERSON tied 4th in NFL with 20 TFL & set career highs in tackles (54) & sacks (12) in 2025. Had TFL in 15 games last season, tied-most (Brian Burns) in NFL. Has 0.5+ sacks in 4 of his past 5, incl. playoffs. Had 6 tackles, 2.5 sacks & PD in last meeting. • DE DANIELLE HUNTER ranked 3rd in NFL with 15 sacks last season, 7th career season with 10+ sacks. Aims for his 7th in row, incl. playoffs, with sack. Had 2 sacks in last meeting. • LB AZEEZ AL-SHAAIR led team with 103 tackles & set career high with 9 PD in 2025. Aims for his 3rd in row vs. Buf. with 7+ tackles & PD. • LB HENRY TO’OTO’O totaled 93 tackles & set career highs in sacks (2.5), TFL (9) & PD (4) in 2025. Had 7 tackles & sack in last meeting. • CB KAMARI LASSITER set career highs in tackles (91), TFL (7) & PD (17) last season. Had PD in 14 games last season, incl. playoffs, tied-most in NFL (Mike Jackson). • S REED BLANKENSHIP can make Hou. debut after spending 1st 4 seasons with Phi.
Game Odds
Buffalo Bills 44.5
Houston Texans Pick
Odds Courtesy of Sports Odd Direct as of Saturday, September 12, 2026
