Venue: Oracle Park, San Francisco, California.
First pitch: 9:45 p.m. ET (6:45 p.m. local).
TV/Streaming: NBC Sports Bay Area (NBCSBA) and Cardinals broadcasts; additional options may include Peacock or Fubo.
Starting Pitchers
Cardinals: LHP Quinn Mathews (1-2, 4.38 ERA, 1.58 WHIP, 24 K in 24.2 IP). Mathews is a young/limited-experience arm with mixed results in a small sample. He offers a left-handed look but has elevated walk and hit rates so far.
Giants: RHP Landen Roupp (8-13, 4.17 ERA, 1.29 WHIP, 137 K in 144.2 IP). Roupp has logged significant innings with solid strikeout totals and better overall command than his counterpart. He provides a more established presence despite a sub-.500 record.
Roupp holds the edge in experience and peripherals.
Weather Forecast
Mild and mostly clear to partly cloudy conditions typical of San Francisco evenings. Highs in the upper 70s to low 80s°F during the day, cooling into the low-to-mid 60s by game time. West winds around 5–10 mph. Very low precipitation chance—excellent conditions for baseball with no significant delay risk.
Injury Reports
Cardinals:
JJ Wetherholt (2B/INF): 10-day IL (wrist; nearing possible return).
Masyn Winn (SS): 10-day IL (thumb).
Peter Strzelecki (RP): 15-day IL (forearm).
Everson Pereira (OF): 10-day IL (hand).
Blaze Jordan (INF) and others on IL. Infield and bullpen depth affected.
Giants:
Victor Bericoto (OF): 10-day IL (knee).
Willy Adames (SS): 10-day IL (elbow).
Marcelo Mayer (INF): 10-day IL (forearm).
JT Brubaker (RP) and multiple longer-term arms (e.g., Matt Gage and others on 60-day IL). Depth is stretched in the infield and bullpen.
Both clubs are managing notable position-player and pitching injuries.
Current Rosters / Key Players
Cardinals key contributors: Alec Burleson (power/production), Iván Herrera, Jordan Walker, Thomas Saggese (hot recently), and supporting pieces providing OBP and contact. Team OBP ranks solidly in the NL.
Giants key contributors: Rafael Devers (elite power/doubles production, ~35 HR), Bryce Eldridge (consistent recent hitting), Jung Hoo Lee, and a mix of veterans and younger talent. They have shown power in streaks.
Key Player vs. Player Matchups
Mathews vs. Giants hitters: Faces a power-oriented core led by Devers’ extra-base threat and Eldridge’s bat. Mathews’ limited sample and elevated WHIP could be tested by patient San Francisco hitters.
Roupp vs. Cardinals hitters: Better command challenges St. Louis’ mix of contact and power (Burleson, Herrera). Roupp’s strikeout ability offers upside against a Cardinals lineup dealing with infield absences.
This is Game 2 of the three-game series (Giants took the opener 5-4 in 11 innings on Monday). Season series is in its early stages.
Recent Team Forms
Cardinals: Competitive but inconsistent (2-3 in recent 5-game samples). 72-73 overall (third in NL Central) and still in the broader wild-card conversation. Solid road mark (38-35).
Giants: 5-5 last 10. 60-85 overall (fourth in NL West) and playing out the string, though capable of opportunistic home wins. They hold a 1-0 series lead.
Series History
Current three-game set at Oracle Park (Giants lead 1-0 after Monday’s extra-inning walk-off). The clubs have limited 2026 meetings so far; historical interleague/NL matchups have been competitive, with Oracle Park’s pitcher-friendly dimensions often playing a role.
Betting Trends
Near-even moneyline reflecting two non-elite starters and similar recent forms. Public interest is moderate; Oracle Park tends to suppress scoring, supporting lower totals. Home underdogs or slight favorites often attract action in late-season interleague play.
Game Odds
St. Louis Cardinals 8
San Francisco Giants – 105
Odds Courtesy of Sports Odds Direct as of Monday, September 7, 2026
