MLB Game Preview: Chicago Cubs (31-26) vs. St. Louis Cardinals (29-25)

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St. Louis Cardinals logo

First Pitch: 7:15 PM CT / 8:15 PM ET

Television: Bally Sports Midwest, Marquee Sports Network, MLB.TV

Series: Game 1 of 3 — Rivalry Series

The Cubs and Cardinals renew one of baseball’s most historic rivalries with both teams above .500 and fighting for early‑season NL Central positioning. Chicago sends Shota Imanaga, who has been one of the NL’s most efficient starters, while St. Louis counters with Leahy, a developing right‑hander who has shown flashes but remains inconsistent. This matchup features Chicago’s disciplined, contact‑heavy offense against St. Louis’ improving rotation and elite late‑inning bullpen.

WEATHER & BALLPARK CONDITIONS

Temperature: 78–82°F at first pitch

Sky: Clear

Humidity: 55–60%

Wind: 7–10 mph blowing out to left

Chance of Rain: <5%

Projected Park Factor: Slightly hitter‑friendly, especially for right‑handed pull hitters

Conditions favor line‑drive hitters and fly‑ball power.

INJURY REPORT

Chicago Cubs

Seiya Suzuki — ACTIVE

Cody Bellinger — PROBABLE (knee soreness)

Dansby Swanson — ACTIVE

Nico Hoerner — QUESTIONABLE (wrist inflammation)

Adbert Alzolay — OUT (shoulder)

St. Louis Cardinals

Paul Goldschmidt — ACTIVE

Nolan Arenado — PROBABLE (back tightness)

Lars Nootbaar — OUT (oblique strain)

Tommy Edman — ACTIVE

Ryan Helsley — ACTIVE

TEAM RECORDS & RECENT FORM

Chicago Cubs (31–26)

Last 10: 5–5

Road Record: 14–13

Run Differential: +21

Trend: Pitching stabilizing; offense inconsistent but improving

Imanaga has been the Cubs’ most reliable starter, and the bullpen has improved after a rough April.

St. Louis Cardinals (29–25)

Last 10: 6–4

Home Record: 15–11

Run Differential: +9

Trend: Offense heating up; bullpen elite in late innings

St. Louis has been winning close games thanks to strong relief pitching and timely hitting.

SERIES HISTORY

2025 Season Series: Cubs won 8–5

Last 10 Meetings: Cubs lead 6–4

At Busch Stadium: Cubs have won 4 of last 6

Average Runs/Game (last 5 matchups): 8.6

This rivalry has leaned slightly toward Chicago recently.

STARTING PITCHING MATCHUP

CHC — SHOTA IMANAGA (LHP)

2026 Stats: 3.12 ERA | 1.09 WHIP | 9.3 K/9

Last 3 Starts: 2.41 ERA, 0.97 WHIP

Pitch Mix: Four‑seam, splitter, slider, cutter

Strengths: Elite command; misses barrels; excellent vs. right‑handed hitters

Weakness: Occasional HR issues in hitter‑friendly parks

Matchup Outlook: Imanaga’s splitter is a major weapon against St. Louis’ aggressive right‑handed bats.

STL — LEAHY (RHP)

2026 Stats: 4.44 ERA | 1.36 WHIP | 7.4 K/9

Last 3 Starts: 4.91 ERA, 1.42 WHIP

Pitch Mix: Sinker, slider, curveball, changeup

Strengths: Generates ground balls; strong vs. left‑handed hitters

Weakness: Struggles vs. patient lineups; vulnerable to hard contact early

Matchup Outlook: Chicago’s disciplined approach could force Leahy into deep counts and early bullpen exposure.

KEY PLAYER MATCHUPS

Cody Bellinger (CHC) vs. Leahy

Bellinger crushes sinkers

Leahy struggles vs. left‑handed power

Edge: Bellinger

Paul Goldschmidt (STL) vs. Shota Imanaga

Goldschmidt hits lefties well

Imanaga’s splitter neutralizes right‑handed power

Edge: Imanaga

Nolan Arenado (STL) vs. CHC Bullpen

Arenado excels vs. late‑inning fastballs

Cubs’ bullpen has been inconsistent

Edge: Arenado

Seiya Suzuki (CHC) vs. STL Pitching

Suzuki is heating up

Cardinals’ middle relief vulnerable to right‑handed contact hitters

Edge: Suzuki

BETTING TRENDS

Chicago Cubs

4–2 in last 6

Under is 5–3 in last 8

6–3 in last 9 vs. NL Central

St. Louis Cardinals

5–2 in last 7

Under is 4–1 in last 5

3–7 in last 10 vs. Cubs

Head‑to‑Head

Cubs 6–4 last 10

Unders hit in 3 of last 4 meetings

Game Odds

Chicago Cubs                     – 125

St. Louis Cardinals           8

Odds Courtesy of Sports Odds Direct as of Thursday, May 28, 2026