MLB Game Preview: St. Louis Cardinals (17-13) vs. Pittsburgh Pirates (16-15)

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Pittsburgh Pirates logo

Location: PNC Park, Pittsburgh, PA

First Pitch is scheduled for 12:35 p.m. EDT

Weather Outlook

Forecast: Clear conditions with no rain expected.

Source: Match preview indicates “weather will be clean and there are no chances of rain.”

Injury Report

Pittsburgh Pirates

Jared Triolo — 10-Day IL (knee)

Jared Jones — 60-Day IL (elbow)

St. Louis Cardinals

Matt Pushard — 15-Day IL (knee)

Hunter Dobbins — 15-Day IL (knee)

Lars Nootbaar — 60-Day IL (heels)

Starting Pitching Matchup

St. Louis Cardinals — Hunter Dobbins (0-0)

Recently activated but still listed on IL in some reports; expected starter per Doc’s Sports.

Cardinals pitching staff overall: 4.81 ERA, 1.42 WHIP, 200 K, 108 BB, 35 HR allowed.

Pittsburgh Pirates — Paul Skenes (4-1, 2.48 ERA, 0.72 WHIP)

30 strikeouts, elite command and dominance early in 2026.

Pitching Edge: Strongly favors Pittsburgh with Skenes’ elite WHIP and strikeout profile.

Team Records & Recent Form

St. Louis Cardinals (17-13)

Road record: 10-5

Last 10 games: 5-5, .235 AVG, 4.45 ERA, outscored opponents by 2 runs

Pittsburgh Pirates (16-15)

Home record: 8-8

Last 10 games: 4-6, .237 AVG, 4.60 ERA, outscored by 5 runs

Series History

This is the fourth meeting between the teams this season.

Key Player Matchups

Cardinals Hitters

JJ Wetherholt: 5 doubles, 6 HR, 15 RBI

Nathan Church: 10-for-38, 4 HR, 7 RBI last 10 games

Pirates Hitters

Ryan O’Hearn: .317 AVG, 5 HR, 20 RBI

Nick Gonzales: 18-for-40, 2 doubles last 10 games

Betting Trends

Line: Pirates -224 / Cardinals +185; Total 7.5

Cardinals are 7-1 when outhitting opponents.

Pirates are 12-7 when recording 8+ hits.

St. Louis Cardinals           7

Pittsburgh Pirates            – 219

Odds Courtesy of Sports Odds Direct as of Wednesday, April 29, 2026