First pitch is scheduled for 7:40 PM EDT / 6:40 PM CDT / 4:40 PM MST
Venue: American Family Field, Milwaukee, Wisconsin (Brewers’ home)
TV/Streaming: D-backs.TV / Brewers.TV / MLB.TV (nationally available); radio on Arizona Sports 98.7 FM / Brewers Radio Network
Weather Updates
Mild and mostly playable conditions for this early-season interleague matchup. Daytime highs near 59°F with mostly cloudy skies, cooling into the mid-to-upper 40s by first pitch and low-to-mid 40s by late innings. Winds around 10-13 mph (generally from the west/southwest), with a low precipitation chance of 7-25% (isolated light showers possible but unlikely to cause delays). Overnight lows in the mid-40s. American Family Field’s retractable roof is expected to remain open for excellent baseball weather—cooler temps may slightly suppress offense compared to warmer parks, but no major impact anticipated.
Injury Report
Diamondbacks (significant catching and infield depth issues):
C Gabriel Moreno: 10-day IL (left oblique strain, retroactive mid-April) — out until at least early May; key defensive and offensive loss behind the plate.
SS Geraldo Perdomo: Day-to-day (left ankle sprain from April 25) — missed recent games; status uncertain for Tuesday but trending toward availability.
C Adrian Del Castillo: Day-to-day (dislocated left ring finger from April 26 foul tip) — removed early; backup catching depth strained.
RHP Zac Gallen: Day-to-day (right shoulder contusion from April 25) — exited early but not starting tonight.
1B Carlos Santana: 10-day IL (strained groin).
Longer-term absences include Jordan Lawlar (wrist, 60-day IL). Diamondbacks’ lineup and bullpen flexibility are tested, especially with recent Mexico City series wear.
Brewers (major outfield and power bat absences):
1B Andrew Vaughn: 10-day IL (fractured left hamate/hand since late March) — out until mid-May; power and lineup presence missed.
OF Jackson Chourio: 10-day IL (fractured left hand since early April) — out until early May.
OF/LF Christian Yelich: 10-day IL (strained groin since mid-April) — expected return mid-to-late May; massive offensive and leadership void.
Additional: SP Quinn Priester (wrist/thoracic outlet, 15-day IL); RP Jared Koenig (elbow, 15-day IL).
Brewers’ offense is depleted in the heart of the order, relying on depth and recent hot streaks from others like William Contreras.
Starting Pitchers & Key Player Matchups
Diamondbacks: RHP Merrill Kelly (1-1, 9.31 ERA, limited IP with high hard contact allowed)
Kelly has struggled early with command and elevated ERA, allowing too many baserunners and extra-base hits. He faces a Brewers lineup thinned by injuries but still dangerous with contact-oriented bats. Key matchups: How Brewers’ remaining hitters (e.g., Contreras, Turang) exploit any elevated pitch counts or mistakes.
Brewers: RHP Chad Patrick (1-1, 2.35 ERA, strong command with 11+ K in limited starts)
Patrick has been a rotation bright spot with low ERA, solid WHIP, and strikeout ability. Home cooking at American Family Field favors him against a D-backs offense that can be streaky. Royals’ speed/power threats like Corbin Carroll and Ketel Marte could test Patrick’s control, but his early-season dominance gives Milwaukee the clear pitching edge.
Other notable matchups: D-backs’ road offense (solid but inconsistent) vs. Brewers’ home bullpen and defensive shifts. Brewers lean on Contreras’ bat and speed; Arizona counters with Marte/Walker veteran presence amid injuries.
Team Records & Recent Forms
Diamondbacks (15-12, 3rd NL West): Respectable 6-6 on the road. Strong recent surge (7-3 in last 10 games, batting .267+ team-wide), including a Mexico City series split vs. Padres with high-scoring wins. Offense has shown pop but pitching inconsistencies linger.
Brewers (14-13, ~4th NL Central): 8-7 at home. Mixed last 10 (5-5 overall), capped by a dominant 5-0 shutout of the Pirates on April 26. Recent form includes road splits vs. Detroit but home struggles in some spots; pitching has stabilized while offense navigates injuries.
Series History
All-time series is nearly even, with Brewers holding a slim 74-70 edge over 148 meetings (Brewers ~4.6 runs/game, D-backs ~4.4). No 2026 meetings yet—this is the season-series opener (three-game set April 28-30). Recent trends show competitive interleague play, with neither team dominating lately; last handful of seasons have been back-and-forth, often decided by starting pitching.
Betting Trends
Diamondbacks: Over in 6 of last 9 games; 2-4 SU in last 6 but 8-4 SU in last 12 vs. select opponents; road offense capable but pitching vulnerable.
Brewers: 1-4 SU in last 5 but strong home ATS (recent 2-3 L5 overall); totals OVER in 8 of last 14 home games. Public betting split ~50/50.
Pitcher-specific: Massive edge to Patrick (sub-2.50 ERA) over Kelly (9+ ERA); home favorites with superior starters have cashed well early season.
Game Odds
Arizona Diamondbacks 8
Milwaukee Brewers – 126
Odds Courtesy of Sports Odds Direct as of Monday, April 27, 2026
