MLB Game Preview: Chicago Cubs (17-11) vs. San Diego Padres (18-9

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San Diego Padres logo

First Pitch is scheduled for 6:40 p.m. PT (9:40 p.m. ET)

Venue: PETCO Park — San Diego, California

Surface: Natural grass

Weather Forecast — PETCO Park

Temperature: 64–67°F at first pitch

Conditions: Clear, coastal breeze

Wind: 7–10 mph blowing in from right field

Impact: Slight pitcher‑friendly environment; deep outfield suppresses home runs

Injury Report

Chicago Cubs

Seiya Suzuki (OF): Day‑to‑day, oblique tightness

Jameson Taillon (RHP): 15‑day IL, back

Julian Merryweather (RHP): 15‑day IL, shoulder

Michael Busch (1B): Day‑to‑day, hand soreness

San Diego Padres

Fernando Tatis Jr. (OF): Day‑to‑day, ankle soreness

Joe Musgrove (RHP): 15‑day IL, elbow

Luis Campusano (C): Day‑to‑day, knee

Robert Suarez (RHP): Day‑to‑day, forearm fatigue

(Official MLB injury designations will finalize closer to game time.)

Team Records & Recent Form

Chicago Cubs (17–11)

Last 5: W, W, L, W, L

Strengths: Improved lineup depth, strong bullpen performance

Weaknesses: Inconsistent road offense

San Diego Padres (18–9)

Last 5: W, W, W, L, W

Strengths: Elite top‑of‑order production, strong home pitching

Weaknesses: Middle‑relief volatility

Probable Pitching Matchup

Chicago — RHP Justin Steele

Profile: Heavy fastball/cutter mix

Strengths: Weak contact, ground‑ball generation

Keys: Keeping Padres’ right‑handed bats off balance

San Diego — RHP Dylan Cease

Profile: High‑velocity fastball, elite slider

Strengths: Strikeout upside, swing‑and‑miss stuff

Keys: Command; avoiding deep counts

This is one of the premier pitching matchups on the Monday slate — a duel between two frontline right‑handers.

Key Player Matchups

Cody Bellinger (CHC) vs. Dylan Cease

Bellinger handles high velocity well

Cease must bury his slider to avoid damage

Dansby Swanson (CHC) vs. Padres’ Bullpen

Swanson’s late‑inning production has been strong

Padres’ middle relief has been shaky

Manny Machado (SD) vs. Justin Steele

Machado excels vs. left‑handed pitching

Steele’s cutter inside will determine this matchup

Xander Bogaerts (SD) vs. Cubs’ Right‑Side Defense

Bogaerts’ line‑drive profile plays well at PETCO

Cubs’ infield must limit extra bases

Series & Historical Notes

Cubs and Padres split their 2025 season series.

Padres have won 6 of the last 8 meetings at PETCO Park.

Both teams enter above .500 with early‑season momentum.

Betting Trends

Chicago

3–2 in last 5

Unders hit in 4 of last 6

Steele starts often trend low‑scoring

San Diego

4–1 in last 5

Overs hit in 3 of last 5

Cease has been dominant at home

Game Odds

Chicago Cubs                     7.5

San Diego Padres             – 118

Odds Courtesy of Sports Odds Direct as of Sunday, April 26, 2026