First Pitch: 1:10 PM ET Venue: Progressive Field, Cleveland, OH
Weather Outlook (Cleveland, OH – April 22, 2026)
No direct weather data surfaced in search results. Inference: Progressive Field early‑afternoon April games typically feature mid‑50s to low‑60s temperatures, light winds, and low precipitation risk. (If you want, I can pull a historical weather model.)
Injury Report
Houston Astros
A long injury list impacts both pitching depth and lineup flexibility:
Dustin Harris (hand) – Day‑to‑Day
Taylor Trammell (groin) – 10‑Day IL
Brandon Walter (elbow) – 60‑Day IL
Nate Pearson (elbow) – 15‑Day IL
Zach Dezenzo (elbow) – 10‑Day IL
Cody Bolton (back) – 15‑Day IL
Jeremy Peña (knee) – 10‑Day IL
Joey Loperfido (quad) – 10‑Day IL
Ronel Blanco (elbow) – 60‑Day IL
Hunter Brown (shoulder) – 15‑Day IL
Bennett Sousa (oblique) – 15‑Day IL
Jake Meyers (oblique) – 10‑Day IL
Nick Allen (back) – 10‑Day IL
Tatsuya Imai (arm) – 15‑Day IL
Josh Hader (biceps) – 60‑Day IL
Hayden Wesneski (elbow) – 60‑Day IL
Cristian Javier (shoulder) – 60‑Day IL
Cleveland Guardians
Gabriel Arias (hamstring) – 10‑Day IL
Andrew Walters (lat) – 15‑Day IL
Team Records & Recent Form
Houston Astros (9–16)
Road Record: 2–10
Last 5: L–W–L–L–L (1–4)
Last 10: 3–7, .232 AVG, 5.42 ERA, outscored by 12 runs
Cleveland Guardians (14–11)
Home Record: 8–4
Last 5: W–L–W–W–L (3–2)
Last 10: 5–5, .248 AVG, 5.11 ERA
Pitching Matchup
Houston – Peter Lambert (RHP)
0–1, 7.20 ERA, 1.60 WHIP, 8 K
High contact allowed; struggles with long ball.
Cleveland – Tanner Bibee (RHP)
0–2, 4.81 ERA, 1.52 WHIP, 23 K
Better underlying metrics; strong strikeout profile.
Key Player Matchups
Houston
Yordan Alvarez: .326 AVG, 10 HR, 21 RBI, .756 SLG — elite form
Christian Walker: .274 AVG, 5 HR, 18 RBI
Jose Altuve: .281 AVG, .385 OBP
Cleveland
Brayan Rocchio: .286 AVG, 3 HR, 14 RBI
Chase DeLauter: 5 HR, 12 RBI — hit a go‑ahead triple on Apr 21
José Ramírez: 6 HR, 12 RBI, .494 SLG
Series History
This is the third meeting of the season.
Cleveland won 8–5 on April 21 behind a massive 6‑run 8th inning.
Astros won earlier in the series (per ESPN’s “determine series winner” note).
Betting Trends
Houston
5–14 when allowing a home run.
Road struggles (2–10).
Pitching staff ERA: 5.93, WHIP 1.63 (bottom of MLB).
Cleveland
8–2 when scoring 5+ runs.
Strong home performance (8–4).
Game Odds
Houston Astros 8
Cleveland Guardians – 156
Odds Courtesy of Sports Odds Direct as of Tuesday, April 21, 2026
