MLB Game Preview: Cleveland Guardians (9-7) vs. St. Louis Cardinals (8-7)

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St. Louis Cardinals logo

Venue, Date & First Pitch

Stadium: Busch Stadium — St. Louis, Missouri

First pitch is scheduled for 7:45 PM EDT

Weather Outlook (Inference)

No weather data was provided in the sources.
Based on typical mid‑April evenings in St. Louis, expect low‑60s temperatures, light breeze, and neutral hitting conditions. (Inference — not sourced)

Injury Report

Cleveland Guardians

Gabriel Arias — 10‑Day IL (hamstring)

George Valera — 10‑Day IL (calf)

Andrew Walters — 15‑Day IL (lat)

Hunter Gaddis — 15‑Day IL (forearm)

St. Louis Cardinals

Masyn Winn — day‑to‑day (leg)

Matt Pushard — 15‑Day IL (knee)

Hunter Dobbins — 15‑Day IL (knee)

Lars Nootbaar — 60‑Day IL (heels)

Team Records & Season Profile

Cleveland Guardians (9–7)

Road Record: 5–5

AVG: .220

OBP: .309

SLG: .365

Runs per Game: 3.6

Team ERA: 3.66 (11th MLB)

WHIP: 1.22

Strikeouts: 146

HR Allowed: 19

St. Louis Cardinals (8–7)

Home Record: 5–4

AVG (last 10): .209

ERA (last 10): 5.10

Run Differential (last 10): –14

3–0 when out‑hitting opponents

Recent Team Form

Guardians — Last 10 Games

Record: 6–4

AVG: .243

ERA: 3.78

Run Differential: +1

Cardinals — Last 10 Games

Record: 5–5

AVG: .209

ERA: 5.10

Run Differential: –14

Pitching Matchup

Cleveland — Gavin Williams (RHP)

Record: 1–1

ERA: 2.04

WHIP: 1.07

Strikeouts: 25

Additional analytics:

Williams is given a longer leash than average pitchers, throwing 6.9 more adjusted pitches per game, increasing his likelihood of deeper outings.

St. Louis — Matthew Liberatore (LHP)

Record: 0–0

ERA: 3.38

WHIP: 1.50

Strikeouts: 10

Additional analytics:

Liberatore has increased his changeup usage by 7.7%, a pitch associated with improved effectiveness.

Pitching Edge: Slightly Cleveland — Williams has been sharper and more efficient.

Key Player Matchups

1. Jordan Walker (STL) vs. Guardians Pitching

Leads Cardinals with 9 extra‑base hits, including 7 HR.

Advantage: Cardinals — Walker is their most dangerous bat.

2. Chase DeLauter (CLE) vs. Cardinals Pitching

5 HR, .680 SLG — elite early‑season power.

Advantage: Guardians — DeLauter is their top slugger.

3. Angel Martinez (CLE) vs. Liberatore

12‑for‑35, 2 doubles, HR, 6 RBI in last 10.

Advantage: Guardians — Martinez is red‑hot.

4. Ramon Urias (STL) vs. Williams

6‑for‑26, 2 HR in last 10.

Advantage: Slightly Cardinals — Urias has been productive.

Series History

First meeting of the 2026 season.

Guardians are 7–2 when recording 8+ hits.

Cardinals are 3–0 when out‑hitting opponents.

Betting Trends

Cleveland

7–2 when recording 8+ hits.

Strong pitching: 3.66 ERA, 1.22 WHIP.

Bullpen: 83.3% save rate (5-for-6).

St. Louis

5–4 at home.

3–0 when out‑hitting opponents.

Offense inconsistent (last 10: .209 AVG).

Game Odds

Cleveland Guardians      – 120

St. Louis Cardinals           8

Odds Courtesy of Sports Odds Direct as of Sunday, April 12, 2026