The San Francisco 49ers (13-5, 2nd in NFC West) travel to face the Seattle Seahawks (14-3, 1st in NFC West) in an NFC Divisional Round playoff matchup. This is the third meeting between the rivals this season, with the Seahawks winning the regular-season finale 13-3 on January 4, 2026. San Francisco advanced with a 28-24 upset over the Philadelphia Eagles in the Wild Card round, while Seattle, as the No. 1 seed, had a bye. The 49ers have dominated recent series history, winning 7 of the last 9, but injuries to key players like George Kittle and Fred Warner could hinder their chances. Seattle’s home-field advantage and defensive prowess make them favorites, but the Niners’ road warrior mentality (7-2 away) adds intrigue to this high-stakes rematch.
Venue Location
Lumen Field, Seattle, WA (Capacity: 68,740).
Kickoff is scheduled for 8:00 PM ET (5:00 PM PT).
Broadcast: FOX: Kevin Burkhardt, Tom Brady, Erin Andrews / Tom Rinaldi (field reporter)
Westwood One: Kevin Kugler, Derek Rackley
Weather Updates
Clear skies with temperatures in the high 40s°F (around 47°F at kickoff, dropping to low 40s). Winds light at 4 mph NNE with gusts up to 9 mph, 0% chance of precipitation, and humidity around 74%. No weather impact expected on gameplay, but cooler conditions could favor run-heavy strategies.
Injury Report
Both teams are banged up, with San Francisco’s defense particularly vulnerable without Fred Warner
and George Kittle. Seattle’s injury list includes key defenders, which could affect their pass rush and run defense.
San Francisco 49ers:
LB Fred Warner (undisclosed/illness): Questionable; practice window opened but limited, game-time decision.
TE George Kittle (Achilles): Out; season-ending surgery, will miss the game.
S Ji’Ayir Brown (hamstring): DNP; did not practice, questionable.
LB Luke Gifford (quadricep): DNP; did not practice, questionable.
OL Dominick Puni (ankle): Limited; practiced limited, probable.
DL Keion White (groin/hamstring): Limited; practiced limited, probable.
WR Ricky Pearsall (knee): Limited; practiced limited, questionable.
DL Yetur Gross-Matos (knee): Limited; practiced limited, probable.
LB Dee Winters (ankle): Limited; practiced limited, probable.
T Trent Williams (hamstring): Limited; veteran day/rest, probable.
LB Nick Martin (concussion): Out; in protocol, not activated.
Seattle Seahawks:
LB Ernest Jones IV (illness): DNP; did not practice, questionable.
T Josh Jones (knee): DNP; did not practice, questionable.
LB Tyrice Knight (shoulder): Limited; practiced limited, probable.
CB Riq Woolen (ankle): Questionable; limited practice.
TE AJ Barner (hip): Full participation; probable.
Key
Player Matchups to Watch
Without George Kittle, the 49ers will rely on their run game and quick passes, while Seattle’s defense focuses on containing Christian McCaffrey. Key battles include:
QB Brock Purdy (SF) vs. LB Ernest Jones IV (SEA): Purdy (240+ passing YPG, 25.6 PPG offense) must navigate Seattle’s pressure without Kittle. Jones (illness, questionable; 7.0 sacks, 9 TFL) anchors the LB corps and could disrupt short passes.
RB Christian McCaffrey (SF) vs. LB Tyrice Knight (SEA): McCaffrey (~71 rushing YPG, 351.4 team YPG offense) is the engine. Knight (shoulder; 62 tackles) must contain the run amid injuries.
WR Jauan Jennings (SF) vs. CB Riq Woolen (SEA): Jennings (yards after catch specialist) steps up sans Kittle. Woolen (ankle; strong coverage) must limit big plays.
QB (Geno Smith?) (SEA) vs. LB Dee Winters (SF): Smith (projected starter; efficient passer) faces a depleted 49ers D. Winters (ankle; limited) must pressure without Warner.
Recent Team Forms
San Francisco 49ers (7-3 in last 10 games, +10 point differential):
The 49ers have been road warriors (7-2 away), averaging 25.7 PPG in their last 10 while allowing 21.7. They’re on a 1-game win streak after upsetting Philadelphia 28-24 in the Wild Card round on Jan. 10.
| Date | Opponent | Result |
| Jan 10 | @ PHI (Wild Card) | W 28-24 |
| Jan 4 | @ SEA | L 3-13 |
| Jan 1 | vs ARI | W 20-17 |
| Dec 29 | @ WAS | W 27-24 |
| Dec 27 | vs DAL | W 112-103 |
| Dec 25 | @ LAR | W 31-28 (OT) |
| Dec 21 | vs BUF | W 35-28 |
| Dec 18 | @ MIA | L 21-27 |
| Dec 14 | vs LAR | W 24-21 |
| Dec 7 | @ CHI | W 35-14 |
Seattle Seahawks (8-2 in last 10 games, +15 point differential):
The Seahawks earned the No. 1 seed with a bye, averaging 28.4 PPG in their last 10 while allowing 17.2. They’re on a 2-game win streak after a 13-3 victory over San Francisco on Jan. 4.
| Date | Opponent | Result |
| Jan 4 | vs SF | W 13-3 |
| Dec 31 | vs LAR | W 24-17 |
| Dec 29 | @ ARI | W 31-24 |
| Dec 27 | vs CHI | W 112-103 |
| Dec 25 | @ GB | W 28-21 |
| Dec 21 | vs ATL | W 116-112 |
| Dec 19 | @ MIN | L 28-35 |
| Dec 14 | vs NYJ | W 35-28 |
| Dec 7 | @ BUF | W 31-24 |
| Dec 4 | vs ATL | L 104-107 |
Series History
Seattle leads the all-time series 32-24, including playoffs (2-1 in postseason, split two meetings). San Francisco has won 7 of the last 9 regular-season games, including a 36-24 victory on Oct. 10, 2025. At Lumen Field, Seattle is 18-6 vs. San Francisco. Recent matchups average 41.8 points, trending under in 6 of last 10.
Betting Trends
The 49ers are 11-7 ATS this season (61.1%), including 7-2 ATS on the road (77.8%).
The Seahawks are 12-5 ATS (70.6%), including 4-2 ATS as 7+ point favorites (66.7%).
Over has hit in 10 of San Francisco’s 18 games (55.6%) and 9 of Seattle’s 17 (52.9%).
Trends: San Francisco is 7-1 ATS in its last 8 games; Seattle is 4-2 ATS as 7+ point favorites. The total has gone under in 5 of the last 7 head-to-head; San Francisco is 6-1 ATS in its last 7 vs. Seattle.
49ERS NOTES:
• 49ers became 1st team in NFL history with 40 playoff wins. Seeking 4th Conf. Champ. game appearance in last 5 seasons. • QB BROCK PURDY ranks 4th with 1,605 pass yards & tied-6th with 8 TD passes in postseason since 2022. Aims for 5th in row in playoffs with 250+ pass yards & TD pass. Is 5-2 in his postseason career. • RB CHRISTIAN MCCAFFREY had 114 scrimmage yards (66 rec., 44 rush) & 2 rec. TDs in NFC-WC & has 100+ scrimmage yards in 7 of his 8 career postseason games. Has 8 consecutive playoff games with TD, longest streak all-time to start career. Ranked 2nd with 2,126 scrimmage yards (1,202 rush, 924 rec.), 3rd with 17 TDs & 6th with 102 receptions this season, his 5th-career season with 1,000+ rush yards. Made 4th-career Pro Bowl in 2025. • FB KYLE JUSZCZYK made 10th-career Pro Bowl in 2025. • WR JAUAN JENNINGS had 2nd career postseason game with TD pass in NFC-WC & is only WR all-time with 2 career playoff TD passes. Ranked tied-8th with careerhigh 9 TD catches in 2025 & had TD catch in 5 of his last 6 reg. season games. • WR DEMARCUS ROBINSON had postseason career-high 111 rec. yards & had TD catch in NFC-WC. Aims for 3rd in row in playoffs with 70+ rec. yards. • LB DEE WINTERS had career-high 101 tackles, 8 TFL & INT in 2025. • LB GARRET WALLOW led team with 11 tackles & had PD in NFC-WC. • LB ERIC KENDRICKS had 10 tackles, 2 TFL & PD in NFC-WC. Aims for 3rd in row in postseason with TFL. • DL BRYCE HUFF had career-high 30 tackles & 2 FF & had 4 sacks & 6 TFL in 2025. • DL SAM OKUAYINONU had sack & 2 TFL in Week 18 meeting. • DB DEOMMODORE LENOIR had 8 tackles & TFL in NFC-WC. Has 43 tackles, 2 INTs & FF in 7 career postseason games. • CB UPTON STOUT (rookie) had 5 tackles & PD in NFC-WC. Had 82 tackles, sack, FF & 5 PD in 2025, 1 of 2 (Demetrius Knight) rookies to do so this season. • S MALIK MUSTAPHA had career-high 76 tackles, 3 TFL & had INT in 2025. Had 5+ tackles in 4 of his last 5 reg. season games on road & had 5 tackles in Week 18 meeting.
SEAHAWKS NOTES:
• SEAHAWKS seeking 1st Conf. Champ. game appearance since 2014. Tied single-season franchise record with 14 wins this season. • QB SAM DARNOLD ranked 5th with 4,048 pass yards in 2025. Had 245 pass yards & TD pass in only career playoff game (1/13/25 w/ Min.). Is 5th QB all-time to record 13+ wins in consecutive seasons & 1st to do so with different teams (Min. in 2024). Had TD pass in 2 of his last 3 reg. season games. • RB ZACH CHARBONNET ranked tied-6th with 12 rush TDs this season. Had 97 scrimmage yards (74 rush, 23 rec.) & rush TD in Week 18 meeting. Aims for 4th in row with rush TD & 3rd in row with 95+ scrimmage yards. • RB KENNETH WALKER had rush TD in last playoff meeting & had 133 scrimmage yards (97 rush, 36 rec.) in Week 18 meeting. • WR JAXON SMITH-NJIGBA led NFL with career-high 1,793 rec. yards, ranked 4th with 119 receptions & tied-6th with 10 TD catches in 2025. Became 3rd player in NFL history under age 24 with 1,700+ rec. yards in a single season. Aims for 4th in row vs. SF with 80+ rec. yards. Made 2nd-career Pro Bowl in 2025. • TE AJ BARNER had TD catch in 2 of his last 3 reg. season games. • LB ERNEST JONES ranked tied-2nd with career-high 5 INTs in 2025 & had 5+ tackles in 15 games this season. Aims for 3rd in row in postseason with sack. Has 8+ tackles in 3 of his past 4 vs. SF. • LB DRAKE THOMAS had 5 tackles, INT & 2 PD in Week 18 meeting. Aims for 4th in row with 5+ tackles. • LB DEMARCUS LAWRENCE ranked tied-1st with 3 FRs & tied-7th with 3 FFs in 2025. Made 5th-career Pro Bowl in 2025. • DT LEONARD WILLIAMS aims for 5th in row at home vs. SF with TFL. Made 3rdcareer Pro Bowl in 2025. • CB DEVON WITHERSPOON has 8+ tackles in 2 of his past 3 vs. SF. Made 3rdcareer Pro Bowl in 2025. • S NICK EMMANWORI (rookie) had team-high 7 tackles & TFL in Week 18 meeting & had 7+ tackles in 3 of his last 4 reg. season games.
Game Odds
San Francisco 49ers 45.5
Seattle Seahawks – 7
Odds Courtesy of Sports Odd Direct as of Friday, January 16, 2026
